慢性心力衰竭患者血尿酸和血清胆红素异常的临床意义  

Clinical significance of serum uric acid and serum bilirubin in patients with chronic heart failure

作　　者：郑文权[1] 张洁[1] 林群锋[1] 

机构地区：[1]上海市第六人民医院奉贤分院心内科,上海201400

出　　处：《海南医学》2010年第7期6-8,共3页Hainan Medical Journal

摘　　要：目的探讨慢性心力衰竭(CHF)患者血尿酸(UA)和血清胆红素异常的变化及其临床意义。方法选择72例CHF患者为研究组,按心功能分级分为2组:心功能Ⅲ-Ⅳ级组41例;心功能Ⅱ级组31例。另外选取30例心功能正常者作为对照组。所有病例入院当天或第2天测定其血尿酸和血清胆红素水平,其中心功能Ⅲ-Ⅳ级患者治疗1周后复查血尿酸和血清胆红素。结果与心功能正常对照组及心功能Ⅱ级患者比较,心功能Ⅲ-Ⅳ级患者血尿酸及血清胆红素水平明显升高(P<0.01);治疗一周,心衰有效纠正后,复查血尿酸和血清胆红素水平明显下降(P<0.01)。心功能Ⅱ级患者血尿酸和血清胆红素水平与对照组比较差异无统计学意义。结论对慢性心衰患者观测血尿酸和血清胆红素水平有助于判断心衰严重程度及其治疗效果。Objective To investigate the variational rule and clinical significance of serum uric acid and serum bilirubin in patients with chronic heart failure （CHF）. Methods 72 cases with CHF were taken as study group. Among them, 41 patients with CHF classified as functional classes Ⅲ - Ⅳ of New York Heart Association （NYHA） and 31 with functional classes Ⅱ. 30 cases with normal cardiac function were taken as control group. Serum uric acid and serum bilirubin were detected on the first or second day of admission in all patients and one week later in those with functional classes Ⅲ - Ⅳ. Results The Levels of serum uric acid （UA） and serum bilirubin in patients with functional classes Ⅲ - Ⅳ were significantly higher than those with functional classes 11 and normal controls （P 〈 0.01 ）. One week later, after effective treatment against CHF, the levels of UA and serum bilirubin decreased significantly （P 〈0.01 ）. No differences were observed in patients with functional classes 11 and normal controls. Conclusion Dynamic observation of serum uric acid and serum bilirubin will help to evaluate the severity, therapeutic efficacy in patients with heart failure.

关 键 词：心力衰竭 尿酸 胆红素 

分 类 号：R541.6[医药卫生—心血管疾病]