芪棱汤对脑缺血再灌注大鼠脑微血管PECAM-1表达的影响  

Effect of the Expression of PECAM-1 for Qileng-decotion on Brain after Cerebral Ischemia Peperfusion Rat

作　　者：周荣峰[1] ZHOU Rong-feng （Baoan Distriet, Shiyan People＇s Hospital,Shenzhen 518108,China ）

机构地区：[1]广东省深圳市宝安区石岩人民医院,广东深圳518108

出　　处：《医学信息》2010年第4期886-888,共3页Journal of Medical Information

摘　　要：目的研究芪棱汤对脑缺血再灌注大鼠脑微血管PECAM-1表达的影响。方法将大鼠随机分为假手术组、模型组、对照组、治疗组。采用颈内动脉线栓法复制大鼠脑缺血再灌注（MCAo／Reperfusion）模型。在再灌注不同时点采用免疫组织化学法测PECAM-1。结果假手术组极少PECAM-1表达；各相应再灌注时间点，治疗组及对照组比模型组的PECAM-1表达明显减少（P〈0．01），且治疗组与对照组有显著差异（P〈0．01）。结论芪棱汤可能通过抑制PECAM-1表达而阻抑脑缺血损伤炎症反应。Objective To study the effect of the expression of PECAM-1 in Qileng -decoction on brain after cerebral ischemia repedusion rat. Methods The rats were randomly divided into 4 groups including the sham-operation group,the MCAO （Middle Cerebral Artery Occlusion） group, the control group and the treatment group.the MCAO model was established with method of internal carotid artery occlusion by suture. PECAM-1 was observed with immunohistochemistry method at different reperfusion time. Results There were few PECAM-1 positive in the sham-operating group, the expression of PECAM-1 in the treatment group and the control group were lower than that in the MACO group at different reperfusion time.（P 〈 0.01 ）,and the difference between the treatment group and the control group was significant （P 〈0.01 ）. Conclusion The function of Qileng decoction on inflammatory cascade in cerebral ischemial diseases is probably by intervention of the expression of adhesion molecules.

关 键 词：脑缺血再灌注损伤 芪棱汤 血小板内皮细胞粘附分子-1 

分 类 号：R277.733.1[医药卫生—中医学]