亚急性砷中毒452例的临床表现与尿砷值关系的探讨  

Relationship between the clinical manifestations and the urine arsenic value in 452 cases of the subacute arsenic intoxication

作　　者：农康[1] 葛宪民[1] 苏素花[1] 梁启荣[1] 李航天[1] 苏旭[1] 黄家乐[1] 杨光照[1] 庞丽[1] 韦云秋[1] 陆柳[1] 卢世玲[1] 庞洲东[1] 

机构地区：[1]广西壮族自治区职业病防治研究院,南宁530021

出　　处：《中国临床新医学》2010年第3期212-215,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西壮族自治区医疗卫生重点科研课题(编号:桂卫科字Z2006308号);科技部国家十一五科技支撑项目(编号:2007BAI07A17-14)

摘　　要：目的探讨452例亚急性砷中毒患者临床表现与尿砷值的关系。方法对砷污染饮用水致亚急性砷中毒452例的临床表现、诊断和实验室检查结果进行分析。结果饮用水的砷含量分别为3.19mg/L和3.26mg/L,分别超标318倍和325倍;452例初检尿砷值为0.24～11.2mg/L[(1.41±1.52)mg/L];中毒患者出现消化系统、心血管系统和神经系统的症状分别为389、249和359例;心肌酶、肝功能、肾功能、血常规和尿常规异常分别为237、98、76、91和140例;心电图异常106例。全组452例均诊断为亚急性砷中毒,其中轻、中、重度中毒分别为370、74和8例;中毒患者尿砷含量与受损的器官数及诊断分级呈正相关关系,具有统计学意义(r=0.552,r=0.678,P均<0.01)。结论尿砷值可作为亚急性砷中毒诊断及分级的重要指标。Objective To analyze the relationship between the clinical manifestations and the urine arsenic value in 452 cases of subacute arsenic intoxication. Methods The clinical manifestations, the diagnosis and the laboratory check result in 452 cases of subacute arsenic intoxication led by the tap wate of arsenic pollution were analyzed. Results Tile arsenic content of tap water was 3. 19 mg/L and 3.26 mg/L, exceeded 318 times and 325 times of the allowed figures. The urine arsenic value initially examined in 452 cases were 0. 24 - 11.2 mg/L （ 1.41 ± 1.52 mg/L）. In the 452 patients, 389,249 and 359 eases presented the symptoms of digesting system, the cardiovascular system and nervous system respectively, and 237, 98, 76, 91, 140 and 106 cases presented anomalies of cardiac muscle enzyme, the liver function, the kidney function, the routine blood test, the routine urine test, and electrocardiogram respectively. The numbers of patients diagnosed as the light, moderate, and severe poisoning were 370, 74 and 8 cases respectively. In these patients, the urine arsenie content was positively correlated with the injured organ number and the diagnosis gradation（r = 0. 552,r = 0. 678,P 〈 0. 01 ,respectively）. Conclusion On the basis of analysed results, the urine arsenic content is a important indicator for diagnosis of the subacute arsenic intoxication and grades.

关 键 词：亚急性砷中毒 临床表现 尿砷 诊断分级 

分 类 号：R595.2[医药卫生—内科学]