2:1球浆比换血治疗新生儿高胆红素血症前后血常规的变化  

The change in routine blood before and after the 2:1 ball-oplasm ratio exchange transfusion in the treatment of neonatal hyperbilirubinemia

作　　者：王兆康 梁丹凤 吴宝珍 

机构地区：[1]南宁市宾阳县人民医院新生儿科,广西530405

出　　处：《中国临床新医学》2010年第3期230-232,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的观察2∶1球浆比换血疗法对新生儿高胆红素血症患者血常规影响规律。方法回顾2005-01～2009-04我科因高胆红素血症采用不同球浆比换血治疗的新生儿76例,观察组44例用2∶1球浆比换血,对照组32例采用1∶1球浆比换血;检测换血前后胆红素(Bil)、白细胞(WBC)、红细胞(RBC)、血红蛋白(HB)、血小板(PLT)等指标。结果观察组换血后RBC、Hb均升高,对照组换血后RBC、Hb下降,两组WBC、PLT明显下降。结论 2∶1球浆比换血治疗重症胆红素血症可明显降低血胆红素水平及纠正贫血;但换血后易出现一过性WBC和PLT降低;提示换血后应预防感染、出血的发生,及时采取相应治疗措施,避免出现严重换血后并发症。Objective To observe the effect of the 2：1 ball-plasma ratio exchange transfusion therapy on routine blood of newborn with hyperbilirubinemia. Methods From January 2005 to April 2009 76 newborns with hyperbilirubinemia in our department were treated with different ball plasma ratio exchange transfusion. Of them, the observation group（ n = 44） was treated with the 2：1 ball-plasma ratio exchange transfusion;the control group （n = 32 ） with the 1：1 ball-plasma ratio exchange transfusion. Before and after exchange transfusion, bilirubin, WBC, RBC, hemoglobin and platelets were measured. Results After exchange transfusion, RBC and hemoglobin （Hb） in the observation group increased, while RBC and hemoglobin decreased in the contyol group. There were significant differ- ence betwten two groups （P 〈 0. 05 ）. WBC and platelets in two groups decreased significantly（ P 〈0. 05 ）. Conclusion The 2：1 ball-plasma ratio exchange transfusion treatment for severe hyperbilirubinemia can significantly reduce serum bilirubin levels and correct anemia, but easily lead to transient decrease of white blood cells and platelets after exchange trausfusion. Therefore, after exchange transfusion, it should be necessary to guard against the occurrence of infection and bleeding, and promptly take appropriate therapeutic measures to avoid serious complications after exchange transfusion.

关 键 词：2:1球浆比 换血疗法 新生儿 高胆红素血症 血常规变化 

分 类 号：R722.17[医药卫生—儿科]