喷他佐辛超前镇痛在腹腔镜胆囊切除术中的应用  

The application of pentazocine preemptive analgesia in laparoscopic cholecystectomy

作　　者：孙鼐[1] 刘晓刚[1] 李正凯[1] 

机构地区：[1]郑州市中心医院麻醉科,河南450007

出　　处：《中国临床新医学》2010年第3期250-252,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的观察喷他佐辛对腹腔镜胆切除术(LC)是否具有超前镇痛作用。方法将60例择期LC患者(ASA分级Ⅰ～Ⅱ级)随机分为研究组和对照组。观察24h内恶心、呕吐、瘙痒等不良应的发生率。研究组在全麻诱导前静脉缓慢推注喷他佐辛0.5mg/kg。对照组给予生理盐水推注。记录自主呼吸恢复时间、睁眼时间、拔管时间及术后1、2、4、8、12、24h的疼痛程度并进行评价。结果两组呼吸恢复时间、睁眼时间、拔管时间差异元统计学意义(P>0.05);研究组疼痛程度明显低于对照组(P<0.05);术后患者的并发症的发生情况差异无统计学意义(P>0.05)。结论术前应用喷他佐辛0.5mg/kg能有效减轻腹腔镜胆囊切除术的术后疼痛,起到超前镇痛作用,是一种理想的长效中枢性镇痛方法。Objective To observe the role of preemptive analgesia of pentazocine in laparoscopic cholecystectomy （LC）. Methods Sixty patients with elective LC （ ASA grade Ⅰ to grade Ⅱ） were randomly divided into pre-emptive analgesia group and the control group. Within 24 h, the incidence of nausea, vomiting, itching, etc. were observed. Pre-emptive analgesia group （A group） received intravenous slow bolus injection of pentazocine 0. 5 mg/kg, induction of general anesthesia. The control group （ B group） were injected with saline. The spontaneous breathing recovery time, eyes open time and extubation time and pain assessment at 1, 2, 4, 8, 12, 24 h of treat- ment were recorded. Results The difference in breathing recovery time, eyes open time and extubation time between two groups was not statistically significant（ P 〉 0. 05 ）. The pain intensity in A group was significantly lower than that in group（ P 〈 0. 05 ）. The occurrence of postoperative complications between two groups was no significant difference （P 〉 0. 05）. Conclusion Preoperative application of pentazocine 0. 5 mg/kg can effectively reduce the postoperative laparoscopic cholecystectomy pain, with a role of preemptive analgesia,is an ideal long-term central analgesia.

关 键 词：喷他佐辛 腹腔镜胆囊切除术 超前镇痛 

分 类 号：R614.3[医药卫生—麻醉学]