单核苷酸多态性检测方法的研究进展  

Research Development of Detection Methods in Single Nucleotide Polymorphisms

作　　者：汤桂丽[1] 赵映兰[2] 

机构地区：[1]中国人民解放军第324医院检验科,重庆400020 [2]第三军医大学西南医院药剂科,重庆400038

出　　处：《中国药业》2010年第7期1-3,共3页China Pharmaceuticals

摘　　要：单核苷酸多态性(single nucleotide polymorphism,SNP)作为第3代遗传标记,具有数量多、分布广泛等特点,已成为人类后基因组时代的主要研究内容之一,广泛应用于疾病相关分析、群体遗传学及药物研究等领域,因此建立高度自动化和高通量的SNP检测分析技术十分重要。该文介绍了几种SNP检测技术,特别是生物传感器用于检测SNP的原理,并对高通量的SNP检测技术进行了展望。Single nucleotide polymorphism （SNP） is the third generation of genetic marker. It is widely distributed in the human genome and has become one of the main tasks in the post- genome era. Consequently, a robust and flexible technique for SNP typing is essential, so the latest genotyping technologies and the relative detection are introduced in this paper. Moreover, the way to the high- throughput genotyping in the future is briefly discussed.

关 键 词：单核苷酸多态性 生物传感器 进展 

分 类 号：R446.1[医药卫生—诊断学]