藻酸双脂钠联合辛伐他汀对青年混合型高脂血症患者血管内皮功能的影响  

Effect of Simvastatin Plus Polysaccharide Sulfate on Serum Nitric Oxide and VEGF in Young Adult Patients with Combined Hyperlipidemia

作　　者：刘娟[1] 刘莹[2] 

机构地区：[1]湖北省襄樊市中心医院心内二科,湖北襄樊441000 [2]湖北省随州市中心医院心胸外科,湖北随州441300

出　　处：《中国药业》2010年第7期6-7,共2页China Pharmaceuticals

摘　　要：目的探讨藻酸双脂钠联合辛伐他汀对青年混合型高脂血症患者血管活性物质及其对内皮依赖的舒张功能的影响。方法给予45例青年混合型高脂血症患者辛伐他汀20mg,每晚顿服,藻酸双脂钠0.1g静脉滴注,每天1次,连用2周。比较治疗前后患者血清中一氧化氮(NO)和血管内皮生长因子(VEGF)浓度的变化。结果青年混合型高脂血症患者治疗后血清NO及VEGF均明显升高。结论青年混合型高脂血症可影响NO及VEGF的分泌,藻酸双脂钠联合辛伐他汀对防止和延缓动脉粥样硬化的形成有一定作用。Objective To study the effect of simvastatin plus polysaccharide sulfate（PSS） on serum nitric oxide and vascular endothelial growth factor （VEGF） in young adult patients with combined hyperlipidemia. Methods Forty-five young adult patients with combined hyperlipidemia were treated with oral simvastatin（20 mg once every night） plus PSS（0. 1 g by intravenous injection once daily） for 2 weeks. The serum levels of NO and VEGF were compared before and after treatment. Results Administration of simvastatin plus PSS significantly elevated serum NO and VEGF. Conclusion Simvastatin plus PSS have a significant effect on increasing the level of NO and VEGF to prevent and postpone atherosclerosis in the patients with hyperlipidemia.

关 键 词：高脂血症 藻酸双脂钠 辛伐他汀 一氧化氮 血管内皮生长因子 

分 类 号：R969.3[医药卫生—药理学] R972.6[医药卫生—药学]