重度子痫前期孕妇血浆蛋白变化与围产儿结局关系的研究  

Study on relationship between changes of plasma protein in pregnant women with severe preeclampsia and perinatal outcomes

作　　者：贾赞慧[1] 崔满华[1] 杨梅[1] 郑桂英[1] 

机构地区：[1]吉林大学第二医院妇产科,吉林长春130041

出　　处：《中国妇幼保健》2010年第9期1193-1194,共2页Maternal and Child Health Care of China

摘　　要：目的:通过比较重度子痫前期孕妇血浆蛋白的变化对围生儿结局的影响,探讨临床对重度子痫前期孕妇诊治及改善围生儿结局的方法。方法:选取50例重度子痫前期孕妇及其新生儿为病例组,50例正常妊娠孕妇及新生儿为对照组,两组均已排除慢性肝肾疾病患者。分别测空腹血浆蛋白含量,并将病例组分为低蛋白血症组和非低蛋白血症组,回顾性分析病例组和对照组两组间及病例组内血浆蛋白的差异及对围生儿结局(终止妊娠的孕周及新生儿体重)的影响。结果:病例组血浆总蛋白(TP)、白蛋白(Alb)含量、终止妊娠的孕周及新生儿体重均明显低于对照组(P<0.05),而两组间球蛋白(GT)无明显差异。病例组内低蛋白血症组(A组)与非低蛋白血症组(B组)间终止妊娠孕周差异无统计学意义,但新生儿出生体重、Apgar评分均低于后者,且围生儿死亡率亦较高,差异有统计学意义。结论:终止妊娠的孕周是围生儿预后是否良好的重要参数,重度子痫前期孕妇组血浆蛋白含量越低、围生儿的体重越小、Apgar评分越低预后越差,死亡率越高,提示重度子痫前期孕妇血浆蛋白的变化可作为预测围生儿结局的指标,维持母体血浆白蛋白水平有利于改善围生儿结局。Objective：To explore the measures to diagnose and treat pregnant women with severe preeclampsia and improve perinatal outcomes by comparing the effect of plasma protein in pregnant women with severe preeclampsia on perinatal outcomes. Methods：50 pregnant women with severe preeelampsia and neonates were selected as case group, and 50 normal pregnant women and neonates were selected as control group, the cases with chronic liver and renal diseases were excluded. The level of fasting plasma protein in the two groups were detected, then case group was divided into hypoproteinemia group and non - hypoproteinemia group, the effect of difference among the three groups on perinatal outcomes （ gesta- tional week of pregnancy termination and neonatal body weight） was analyzed retrospectively. Results ：The levels of plasma total protein （TP） and albumin （Alb）, gestational week of pregnancy termination and neonatal body weight in case group were significantly lower than those in control group （P 〈0. 05）, but there was no difference in level of globulin between case group and control group. In case group, there was no difference in gestational week of pregnancy termination between hypoproteinemia group and non - hypoproteinemia group, but neonatal body weight and Apgar score in hypoproteinemia group were significantly lower than those in non -hypoproteinenfia group, the perinatal mortality reversed. Conclusion ：The gestational week of pregnancy termination is an important index of predicting perinatal outcomes, the lower the level of plasma protein in pregnant women with severe preeclampsia, the lighter the perinatal body weight was; the lower Apgar score, the worse prognosis, the higher perinatal mortality was, which indicate that the changes of plasma protein in pregnant women with severe preeclampsia can be used as a predictive index of perinatal outcomes, maintaining maternal plasma albumin level is helpful to improve perinatal outcomes.

关 键 词：重度子痫前期 血浆蛋白 围产儿结局 

分 类 号：R715[医药卫生—妇产科学]