围产期妇女合并梅毒的临床治疗分析  

Analysis on clinical treatment of perinatal women complicated with syphilis

作　　者：袁亚仙 

机构地区：[1]浙江省宁波市象山县丹城中心卫生院,315700

出　　处：《中国妇幼保健》2010年第9期1208-1209,共2页Maternal and Child Health Care of China

摘　　要：目的:评价围产期妇女合并梅毒的治疗方法及其对围产儿预后的影响。方法:回顾性分析2004年5月～2009年5月收治的围产期合并梅毒孕妇51例,均经血清学检查确诊,治疗组35例行全程抗梅毒治疗,16例为未治疗组,分析两组患者的围产儿预后、妊娠状况及新生儿发生先天性梅毒的几率。结果:全程抗梅毒治疗组引产率为2.9%,均无死胎及死产情况发生,而未治疗组引产率、死胎及死亡率分别为25.0%(4例)、25.0%(4例)及6.25%(1例)(P<0.01);治疗组先天性梅毒的发生率为8.6%,远远低于未冶疗组的87.5%(P<0.01);治疗组早产发生率为2.9%,显著低于未治疗组的31.3%(P<0.01);治疗组足月产分娩新生儿达34例,占97.1%,而未治疗组足月产仅3例,占18.8%,两组之间差异存在统计学意义(P<0.01)。结论:对于已经确诊的围产期梅毒患者应及时行抗梅毒治疗,可以有效地降低新生儿的死亡率及婴儿先天性梅毒的发生几率,而妊娠期的定期常规检查对于梅毒的筛查也有重要意义。Objective： To evaluate the treatment of perinatal women complicated with syphilis and the effect on perinatal infants. Methods ： Clinical data of 51 perinatal women complicated with syphilis were analyzed retrospectively from May 2004 to May 2009, all the cases were confirmed by serologic examination, 35 cases in treatment group received complete anti -syphilis treatment, 16 cases in untreated group didnt receive complete anti - syphilis treatment. The perinatal outcomes, pregnancy outcomes and incidences of neonatal congenital syphilis in the two groups were compared. Results：The rate of induced labor in treatment group was 2.9%, no fetal death and stillbirth occurred, the rates of induced labor, fetal death and stillbirth in untreated group were 25.0% （4 cases） , 25.0% （4 cases） and 6. 25% （ one case）, respectively （ P 〈 0. 01 ） ; the incidence of neonatal congenital syphilis in treatment group was 8. 6%, which was significantly lower than that in untreated group （87.5%） （P 〈 0. 01 ） ; the incidence of preterm birth in treatment group was 2. 9% , which was significantly lower than that in untreated group （31.3 % ） （P 〈 0. 01 ） ; the amounts of term delivery neonates in treated group and untreated group were 34 cases （97. 1% ） and 3 cases （18. 8% ） , respectively, there was significant difference （P 〈 0.01 ）. Conclusion：The perinatal women complicated with syphilis should receive complete anti -syphilis treatment timely, which can decrease the mortality of neonates and incidence of neonatal congenital syphilis, regular examination of syphilis during pregnancy plays an important role in screening of syphilis.

关 键 词：围产期 梅毒 治疗手段 预防 

分 类 号：R714.7[医药卫生—妇产科学]