老年慢性充血性心力衰竭急性加重期β受体阻滞剂剂量调整预后分析  

Analysis of prognosis about adjustment of β blocker dosage in elderly patients with chronic congestive heart failure of acute exacerbation stage

作　　者：刘时彦[1] 刘丰[1] 吴剑芸[1] 张韶冈[1] 黄为民[1] 

机构地区：[1]广州市第一人民医院老年科,广东广州510180

出　　处：《中国医药导报》2010年第9期29-30,共2页China Medical Herald

摘　　要：目的:探讨老年慢性充血性心力衰竭急性加重期β受体阻滞剂剂量调整对预后的影响。方法:收集2000年1月～2009年5月住院的各种心血管疾病所致慢性心力衰竭急性加重患者96例,在积极处理诱因,合理氧疗,注意水、电解质、酸碱平衡,合理利用利尿剂、血管扩张剂及洋地黄制剂等治疗的基础上,随机分为原β受体阻滞剂剂量减半组(50例)及全停组(46例),观察患者心衰预后。结果:剂量减半组病情进展15例,好转35例;全停组病情进展25例,病情好转21例,剂量减半组较全停组预后好(P<0.05)。结论:老年患者慢性充血性心力衰竭急性加重期减量使用原β受体阻滞剂与停用相比预后良好,值得临床推广应用。Objective： To study the effects of adjustment of β blocker dosage during elderly patients with chronic congestive heart failure in acute exacerbation stage on the prognosis. Methods： 96 inpatients due to chronic congestive heart failure in acute exacerbation induced by cardiovascular diseases from January 2000 to May 2009 were randomly divided into two groups, group A （original β blocker dosage was half, 50 cases） and group B （β blocker dosage was out, 46 cases）. Each group was actively dealt with predisposing cause, on original base of rational oxygen therapy, keeping water, electrolyte with balance, acid-alkali equilibrium, rational use of diuretic agent, vasodilator agent and digitalis. The prognosis of the two groups was observed. Results： The clinical prognosis of group A was significantly better than that of group B, 15 cases were progressed and 35 cases were improved in group A, 25 cases were progressed and 21 cases were improved in group B. The prognosis of group A was better than that of group B, there was a statistically significant difference between the two groups （P〈0.05）. Conclusion： The reduction of using original β blockers in elderly patients with chronic congestive heart failure in acute exacerbation has better prognosis compared with full-stop using, it is worthy of clinical application.

关 键 词：慢性充血性心力衰竭 急性加重期 Β受体阻滞剂 剂量调整 预后 

分 类 号：R541.61[医药卫生—心血管疾病]