我院1120株细菌耐药性分析  

Surveillance of 1120 bacterial resistance from our hospital

作　　者：袁勇[1] 杨勤[1] 何丽霞[1] 高慧[1] 

机构地区：[1]四川省雅安市人民医院药剂科,625000

出　　处：《中国现代医药杂志》2010年第3期43-45,共3页Modern Medicine Journal of China

摘　　要：目的了解我院2009年1～12月全年临床分离菌对各类抗菌药物的耐药性,以指导临床合理使用抗菌药物。方法使用纸片扩散法和CLSI/NCCLS判断标准进行抗菌药物监测。结果临床分离1120株细菌中革兰阳性细菌占28.5%,革兰阴性细菌占71.5%;耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCONS)分别占81.3%和77.3%。产超广谱β-内酰胺酶细菌(ESBLs)株中大肠埃希菌和肺炎克雷伯菌检出率分别为44.6%和47.2%,铜绿假单胞菌对碳青霉烯类亚胺培南耐药率为37%。结论本组资料对本院细菌性感染的治疗和抗菌药物的合理选用具有重要的参考价值。Objective To investigate the drug resistance of clinical isolates from the Ya＇an People＇s Hospital from Jan to Dec in 2009,to guide the doctors to use rationally antibacterial drugs.Methods Antimicrobial susceptibility tests of clinical isolates were performed using Kirby Bauer methods and the results were analyzed according to the standards recommended by CLSI /NCCLS.Results Of 1 120 clinical isolates Gram positive organisms accounted for 28.5%,Gram negative organisms for 71.5%.The detection rates of methicillin resistant Staphylococcus aureus （MRSA） and coagulase negative staphylococci （MRCONS） were 81.3% and 77.3% respectively.ESBLs producing strains accounted for 44.6% in E.coli and 47.2% in Klebsiella pneumoniae.Pseudomonas aeruginosa strains were resistant to imipenem,the rate was 37%.Conclusion Surveillance data of bacterial resistance was the most important and valuable for the guidance of rational selection of antimicrobial agents.

关 键 词：细菌耐药 药敏试验 抗菌药物 

分 类 号：R446.5[医药卫生—诊断学]