阻塞性睡眠呼吸暂停综合征致心律失常作用及其与自主神经的关系  

Obstruction Sleep Apnea Syndrome:Arrhythmia and Autonomic Mechanisms

作　　者：王涛[1] 王野[1] 张树龙[1] 

机构地区：[1]大连医科大学附属第一医院心内科,辽宁大连116011

出　　处：《心血管病学进展》2010年第2期265-269,共5页Advances in Cardiovascular Diseases

摘　　要：阻塞性睡眠呼吸暂停综合征是一种以睡眠中反复发生低通气、觉醒为主要表现的并发多器官损害的全身疾病,可累及心血管系统。心律失常是其中的一种常见并发症,可表现为窦性心动过缓、传导阻滞、心房颤动、室性早搏、夜间猝死。其发生与自主神经密切相关。阻塞性睡眠呼吸暂停综合征造成自主神经功能紊乱,交感和副交感神经功能失衡。副交感神经过度兴奋可以减慢心率,交感神经兴奋在夜间可以诱发室性早搏,两者都有可能引起严重的心血管事件,如窦性停搏和猝死。目前阻塞性睡眠呼吸暂停综合征治疗中以持续呼吸道正通气的效果较为肯定,但是否每个患者都需要,以及合并心律失常是否需要特殊处理仍待进一步研究。Obstruction sleep apnea syndrome （ OSAS ） is characteristic by repetitive interruptions of airflow （ apnea and hypopnea） and arousals during sleep. OSAS is a systemic disease and increases the risk of cardiovascular events including arrhythmia, sinus bradycardia, heart block, atrial fibrillation, ventricular premature beats, and sudden cardiac death. The mechanism is related to the autonomic nervous system and the balance between sympathetic nervous system and the parasympathetic nervous system. A disturbance in which can result in the above conditions. Continuous positive airway pressure is a good choice of treatment for this. However, further study into the use of continuous positive airway pressure for OSAS is needed.

关 键 词：阻塞性睡眠呼吸暂停综合征 心律失常 自主神经 

分 类 号：R766[医药卫生—耳鼻咽喉科] R541.7[医药卫生—临床医学]