肝X受体抗动脉粥样硬化作用研究进展  

Progress in Antiatherosclerotic Effects of Liver X Receptors

作　　者：朱锦[1] 孙建辉[1] 

机构地区：[1]江苏省常州市第一人民医院心内科,江苏常州213003

出　　处：《心血管病学进展》2010年第2期305-309,共5页Advances in Cardiovascular Diseases

摘　　要：肝X受体属于核受体家族成员,通过与视黄醇类X受体结合形成异二聚体,刺激靶基因的表达。其内生性配体为氧化甾醇和胆固醇生物合成途径的中间产物。肝X受体作为胆固醇和脂肪酸代谢的调节者,在脂质代谢中起关键的调控作用。研究发现,肝X受体信号通路在动脉粥样硬化发展中起重要作用。在小鼠模型中,合成的肝X受体激动剂可抑制动脉粥样硬化的发展,其效应可能是源于对相关代谢和炎症基因表达的调控。这使肝X受体成为研究治疗动脉粥样硬化理想的靶基因。Liver X receptors are members of the nuclear receptor superfamily which forms heterodimers, and with the retinoid X receptor stimulates the expression of target genes. Liver X receptors act as regulators of cholesterol and fatty acid metabolism, and lipid metabolism. Research has outlined the importance of liver X receptors signaling pathways in the development of atherosclerosis. In murine models, synthetic liver X receptors agonists inhibit the development of atherosclerosis--an effect that is likely to result from the modulation of both metabolic and inflammatory gene expression. These observations make liver X receptors an attractive agent for therapeutic treatments of atherosclerosis.

关 键 词：肝X受体 动脉粥样硬化 胆固醇逆转运 

分 类 号：R543.5[医药卫生—心血管疾病]