胰腺类癌的临床和病理学特点分析  

Clinical Pathological Characteristics in Pancreatic Carcinoid

作　　者：何晓生[1] 吴小剑[1] 邹一丰[1] 范新娟[1] 汪建平[1] 兰平[1] 

机构地区：[1]中山大学附属第六医院胃肠外科,广东广州510655

出　　处：《中山大学学报（医学科学版）》2010年第1期114-117,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(30872461)

摘　　要：【目的】探讨胰腺类癌的临床和病理学特点。【方法】对1997年1月1日至2007年12月31日期间手术治疗的8例胰腺类癌临床病理资料(如肿瘤标志物、病理免疫组织化学染色、伴发其他肿瘤、误诊率、肿瘤转移率、住院死亡率、手术根治率等)进行回顾性分析,并结合国内外文献探讨胰腺类癌的临床和病理学特点。【结果】肿瘤标志物CEA、CA199、CA125、CA72-4在胰腺类癌的表达阳性率分别为0%,25%,12.5%,0%,病理免疫组织化学染色Syn、CgA、NSE、CK阳性率分别为25%,62.5%,75%,75%。胰腺类癌伴发其他肿瘤为1/4。胰腺类癌误诊率较高,8例患者中有7例误诊为其它肿瘤。胰腺类癌肿瘤总的转移率为50%,住院死亡率为37.5%,而手术根治率为62.5%。【结论】胰腺类癌误诊率高,常规血液肿瘤标志对早期发现胰腺类癌意义不大,确诊需要病理病理,临床预后较差。【Objective】 To explore the clinical pathological characteristics and treatment of pancreatic carcinoid.【Methods】 Eight patients with pancreatic carcinoid were recruited between January in 1997 and December in 2007 for retrospective analysis which involved tumor markers,immunohistostaining,accompanied with other tumors,misdiagnosis,metastasis,in-hospital mortality rate,and so on.The relevant literatures were simultaneously reviewed to comprehend the clinical pathological characteristics of pancreatic carcinoid.【Results】 Tumor markers CEA,CA199,CA125,and CA72-4 in pancreatic carcinoid were 0% ,25% ,12.5%,and 0%,respectively.Specimen immunohistostaining Syn,CgA,NSE,and CK in pancreatic carcinoid were 25%,62.5%,75%,and 75%,respectively.Two pancreatic carcinoids were accompanied by other tumors in 8 cases.The misdiagnosis rate of pancreatic carcinoid （7 / 8） was markedly high.Pancreatic carcinoid possessed high metastasis （50% ）,high in-hospital mortality rate （37.5%） and low radical operation undergone （62.5%）.【Conclusions】 Pancreatic carcinoid was accompanied with high misdiagnosis rate and poor prognosis.Routine sero-markers did not help discover pancreatic carcinoid early.The final diagnosis depended on specimen immunohistostaining with Syn,CgA,NSE,and CK.

关 键 词：类癌 胰腺 临床病理特点 

分 类 号：R657.5[医药卫生—外科学]