利福平相关肾病综合征  

Nephrotic syndrome associated with rifampicin

作　　者：盛晓燕[1] 唐子勇[2] 段京莉[1] 

机构地区：[1]北京大学第三医院药剂科,北京100191 [2]北京大学第三医院肾内科,北京100191

出　　处：《药物不良反应杂志》2010年第1期66-67,共2页Adverse Drug Reactions Journal

摘　　要：1例17岁女性患者因肺结核给予吡嗪酰胺、乙胺丁醇、利福平、异烟肼治疗。2个月后吡嗪酰胺及乙胺丁醇停用,利福平0.45g/d和异烟肼0.3g/d继续应用。又过3个月,患者出现双下肢可凹性水肿,伴乏力、憋气、尿中泡沫多。遂停用利福平及异烟肼。实验室检查:血浆白蛋白(Alb)12.6g/L,血脂(TG)2.11mmol/L,24h尿蛋白5.511～8.283g,肌酐清除率(CCr)181ml/min。给予口服泼尼松龙、对症治疗,并给予吡嗪酰胺、乙胺丁醇、异烟肼巩固疗效。15d后症状好转出院,随访无复发。A 17-year-old women with pulmonary tuberculosis received pyrazinamide,ethambutol,rifampicin,and isoniazid.Two months later,pyrazinamide and ethambutol were stopped and rifampicin 0.45 g/d and isoniazid 0.3 g/d were continued.After another three months,the patient developed pitting edema in both lower extremities,followed by asthenia,short of breath,and frothy urine.Rifampicin and isoniazid were stopped.Laboratory tests revealed the following levels and values：plasma Alb 12.6 g/L,TG 2.11 mmol/L,24-hour urine protein 5.511~8.283 g,CCr 181 ml/min.Oral prednisolone and symptomatic treatment were given.Meanwhile,she was treated with pyrazinamide,ethambutol,and isoniazid for consolidation of therapeutic effect.Fifteen days later,her symptoms improved and she was discharged.She had no recurrence at follow up.

关 键 词：利福平 不良反应 肾病综合征 

分 类 号：R595.3[医药卫生—内科学]