盐酸托利君与硫酸镁治疗早产的临床疗效分析  

Clinical curative effect analysis about premature labor treatment with ritodrine and magnesium sulfate

作　　者：杨治平[1] 杨智英[1] 李江平[1] 

机构地区：[1]中南大学湘雅三医院产科,长沙410013

出　　处：《药物分析杂志》2010年第3期573-576,共4页Chinese Journal of Pharmaceutical Analysis

基　　金：国家自然科学基金项目(30700438);湖南省自然科学基金项目(06JJ30014)

摘　　要：目的:观察盐酸托利君与传统的硫酸镁针剂治疗早产的效果。方法:对50例诊断先兆早产的孕妇作为研究组,给予盐酸托利君治疗;并随机选择50例符合相同条件的的病例作为对照组,给予硫酸镁治疗。观察盐酸托利君与硫酸镁治疗后孕妇的宫缩抑制情况、显效时间、保胎成功率以及用药后孕妇的心率变化、血压及血糖改变、不良反应。结果应用盐酸托利君组孕妇宫缩显著抑制(P<0.01)。结论:盐酸托利君能有效抑制宫缩,对于治疗早产明显优于硫酸镁。虽对心率有一定影响,但仍较为安全,可以在临床上推广使用。Objective：To observe the curative effect of ritodrine and magnesium sulfate on preterm labor treatment.Methods： 50 pregnant women with premature delivery were taken as study group and were given ritodrine;The another 50 with the conditions cases constituted the control group and give magnesium sulfate.Mammal uterine contractility,time of starting therapeutic effectiveness, mission success rate of therapy of premature birth, heart rate,blood pressure,blood glucose and untoward effect were observed in the two groups respectively. Results： Uterine contractility was effectively reduced after giving ritodrine （P0.01）.Conclusion：Ritodrine can reduce uterine activity, and it is more effective than magnesium sulfate for the treatment of premature delivery. Although an increased heart rate can be caused, ritodrine is a safe drug of premature birth and can be widely used clinically.

关 键 词：盐酸托利君 硫酸镁 早产 

分 类 号：R917[医药卫生—药物分析学]