蒙药玉簪花中的甾体化合物  

Steroidal Constituents from Flowers of a Mongolia Herb,Hosta plantaginea (Lam.) Ascherson

作　　者：张金花[1] 解红霞[1,2] 薛培凤[1] 张宏桂[2] 刘心钰[1] 白吉木色[1] 

机构地区：[1]内蒙古医学院药学院,呼和浩特010059 [2]北京中医药大学中药学院,北京100102

出　　处：《中国药学杂志》2010年第5期335-337,共3页Chinese Pharmaceutical Journal

基　　金：内蒙古自然科学基金资助项目(2009BS1203)

摘　　要：目的研究玉簪[Hosta plantaginea(Lam.)Aschers]花的化学成分。方法利用溶剂法进行提取和萃取分部,采用硅胶柱色谱、Sephadex LH-20柱色谱进行分离,利用理化鉴别及现代波谱分析技术鉴定化合物的结构。结果从中分离鉴定了6个甾体化合物,分别为(25R)-5α-螺旋甾烷-2α,3β-二醇(支脱皂苷元)(1),(25R)-2α,3β-二醇-5α-螺旋甾烷-12-酮(曼诺皂苷元)(2),胡萝卜苷(3),支脱皂苷元-3-O-{O-β-D-吡喃葡萄糖基(1→2)-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷}(4),支脱皂苷元-3-O-{O-β-D-吡喃葡萄糖基(1→2)-O-[β-D-吡喃木糖基(1→3)]-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷}(5)和支脱皂苷元-3-O-{O-β-D-吡喃葡萄糖基-(1→2)-O-[O-α-L-呋喃鼠李糖基-(1→4)-β-D-吡喃木糖基(1→3)]-O-β-D-吡喃葡萄糖-(1→4)-β-D-吡喃半乳糖苷}(6)。结论6个化合物均为首次从该植物中得到。OBJECTIVE To investigate the chemical constituents of the flowers of Hosta plantaginea（Lam.）Aschers.METHODS The chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatography and elucidated on the basis of physiochemical properties and spectral analysis.RESULTS Six steroidal compounds were isolated from the flower of H.plantaginea and identified as（25R）-5α-spirostan-2α,3β-diol（gitogenin）（1）,（25R）-2α,3β-diol-5α-spirostan-12-one（manogenin）（2）,daucosterol（3）,gitogenin-3-O-{-O-β-D-glucopyranosyl-（1→2）-O-β-D-glucopyranosyl-（l→4）-β-D-galactopyranoside}（4）,gitogenin-3-O-{O-β-D-glucopyranosyl-（1→2）-O-[β-D-xylopyranosyl-（1→3）]-O-β-D-glucopyranosyl-（1→4）-β-D-galactopyranoside}（5）,gitogenin-3-O-{O-β-D-glucopyranosyl-（1→2）-O-[O-α-L-rhamnopyranosyl-（1→4）-β-D-xylopyranosyl-（1→3）]-0-β-D-glucopyranosyl-（1→4）-β-D-galactopyranoside}（6）.CONCLUSION All of the compounds were isolated from H.plantaginea for the first time.

关 键 词：玉簪花 化学成分 甾体 

分 类 号：R284[医药卫生—中药学]