青蒿叶药材质量标准研究  

Quality Standard of Leaves of Artemisia annua L.

作　　者：张东[1] 杨岚[1] 厉博文[1] 杨立新[1] 冯学峰[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国药学杂志》2010年第5期392-395,共4页Chinese Pharmaceutical Journal

基　　金：<中国药典>2010版一部标准研究课题资助(YS-205;YS-206)

摘　　要：目的制定青蒿叶药材的质量标准,为该药用植物资源的开发利用提供科学依据。方法采用了显微鉴别法、薄层色谱法、HPLC、水分测定法、灰分测定法及浸出物测定法。结果根据10个不同产地青蒿叶测定结果,确定青蒿素含量不低于0.1%,东莨菪内酯含量不低于0.1%,含水分不高于11%,总灰分不高于11%,酸不溶性灰分不高于2%,95%乙醇冷浸出物不低于7%。结论建立了青蒿叶的质量标准。OBJECTIVE To provide scientific basis for the utilization and development of the leaves of Artemisia annua L.by establishing its quality control standard.METHODS The microscopic identification methods were adopted to describe the microscopic characters of the leaves.The bioactive constituents were analyzed by TLC and HPLC.Moisture,ash and the extracts of the leaves were determined by the methods recorded in the Appendix of Chinese Pharmacopoeia（2005）.RESULTS The moisture in the leaves was below 11%,with the total ash content of 11%.The content of acid-insolubal ash was equal or below 2%.The content of cold 90% ethanol extracts was above 7%.The contents of artemisinin and scopoletin in the leaves were above 0.1%.CONCLUSION The quality standard is suitable for the leaves of Artemisia annua.

关 键 词：青蒿 青蒿素 东莨菪内酯 质量标准 

分 类 号：R917[医药卫生—药物分析学]