丛柳珊瑚的化学成分研究  

Chemical Constituents of Gorgonian Coral Paraplexaura sp. from South China Sea

作　　者：李婷[1] 廖小建[1] 徐石海[1] 

机构地区：[1]暨南大学化学系,广州510632

出　　处：《中国药学杂志》2010年第6期420-422,共3页Chinese Pharmaceutical Journal

基　　金：国家863基金(2006AA09Z408);国家自然科学基金资助项目(20772048)

摘　　要：目的研究我国南海丛柳珊瑚(Paraplexaura sp.)的化学成分。方法采用硅胶柱色谱和反相半制备HPLC等方法分离化合物,根据波谱数据和理化常数确定其结构。结果从南海丛柳珊瑚中分离得到9个化合物,鉴定为:胆甾-4-烯-3β,6β-二醇(1)、24-亚甲基胆甾-5-烯-3-羟基-7-酮(2)、神经酰胺(E)-N-2-(1,3-二羟基-4-十八烯基)-十六酰胺(3)、胸腺嘧啶脱氧核苷(4)、尿嘧啶核苷(5)、咖啡因(6)、氨茶碱(7)、胸腺嘧啶(8)、鲨肝醇(9)。结论化合物2～8均为首次从该种属珊瑚中分离得到,其中6、7在植物中较为常见,从丛珊瑚中分离得到尚属首次。OBJECTIVE To study the organic compounds of the Gorgonian Coral Paraplexaura sp. collected from the South China Sea. METHODS The compounds were isolated and purified by silica gel and senti-preparative reverse-phase HPLC （ C18 ）. Their structures were identified by their physical and spectral data. RESULTS Nine compounds were isolated from Paraplexaura sp. , and their structures were identified as cholest-4-ene-3β, 6β-diol （ 1 ）, ergosta-5,24 （ 28 ）-dien-7-one, 3β-hydroxy （ 2 ）, N-2-（ 1,3-di- hydroxyoctadecan-4,8-dieny） -hexadecamide （ 3 ）, thymidine （ 4 ）, uridine （ 5 ）, caffeine （ 6 ） , aminophylline （ 7 ）, thymine （ 8 ） and batyl alcohol （9）. CONCLUSION Compounds 2 -8 were isolated from Paraplexaura so. for the first time, Compounds 6 and 7 are commom in plants, but they were isolated from coral for the first time.

关 键 词：丛柳珊瑚 Paraplexaura sp. 化学成分 

分 类 号：R284[医药卫生—中药学]