高压乳匀法制备氢溴酸高乌甲素固体脂质纳米粒的工艺研究  

Preparation of Solid Lipid Nanoparticles Loading Lappaconitine Hydrobromide by High Pressure Homogenization

作　　者：陈桐楷[1] 李园[1] 林华庆[1] 张蜀[1] 邓红[1] 余楚钦[1] 侯悦翰[1] 

机构地区：[1]广东药学院,广东省药物新剂型重点实验室,广州510006

出　　处：《中国药学杂志》2010年第6期440-443,共4页Chinese Pharmaceutical Journal

基　　金：广州市重大科技专项计划项目(2008A1-E4101)

摘　　要：目的采用高压乳匀法制备了氢溴酸高乌甲素固体脂质纳米粒(LH-SLN),并考察制备过程中的主要影响因素。方法首先通过实验确定制备工艺参数,然后考察各处方因素对包封率和稳定性的影响,最后以包封率为评价指标,采用正交实验设计法确定最优处方。结果本实验制得的LH-SLN的包封率达到70.48%。结论确定的处方较好,工艺可行。OBJECTIVE To prepare solid lipid nanopartieles loading lappaconitine hydrobromide （LH-SLN） by high pressure homogenization, and to study the main factors affecting the preparation of LH-SLN. METHODS The parameters of technology were determined, then the affecting factors of LH-SLN were studied. On the basis of the single factor exploration , the satisfactory formulation was selected by orthogonal design with high entrapment efficiency as standard. RESULTS The average entrapment efficiency of LH-SLN was 70. 48%. CONCLUSION The technique of preparing LH-SLN by high pressure homogenization is feasible.

关 键 词：氢溴酸高乌甲素 固体脂质纳米粒 高压乳匀法 

分 类 号：R944[医药卫生—药剂学]