莫达非尼对小鼠中枢谷氨酸水平的影响  

Effects of Modafinil on Concentration of Glutamic Acid in Mouse

作　　者：栾家杰[1,2] 马张庆[3] 宋建国[3] 

机构地区：[1]皖南医学院弋矶山医院药剂科,安徽芜湖241001 [2]皖南医学院临床药学研究所 [3]皖南医学院定量药理研究所

出　　处：《中国执业药师》2010年第3期13-16,共4页China Licensed Pharmacist

基　　金：皖南医学院中青年科研基金资助项目(WK200703F)

摘　　要：目的:通过研究莫达非尼(modafinil,MOD)用药后小鼠各脑区谷氨酸含量的变化,探讨MOD中枢兴奋作用的可能机制。方法:MOD灌胃给药,测定给药后小鼠脑部各分区谷氨酸含量。结果:MOD使小鼠大脑皮层谷氨酸含量显著增加,该作用呈剂量依赖性,但对其他脑区谷氨酸水平无显著影响。结论:MOD用药后使小鼠大脑皮层谷氨酸含量明显升高,可能与其中枢兴奋作用机制有关。Objective：To determine the glutamic acid content in seven different brain regions of mice,and to explore possible mechanism of central neural system stimulation of MOD.Methods：After oral administration of MOD,the content of glutamic acid was assessed in mouse brain to discuss the possible central stimulation mechanism of MOD.Results：Glutamic acid content in mouse cortex significantly increased after treatment of MOD and had a significant correlation with the brain drug concentration.Conclusion：MOD is easy to get through the blood-brain barrier and wildly distributed in the mouse brain.MOD effectively increases glutamic acid level in mouse cortex,which can be probably involved in the central stimulation of MOD.

关 键 词：莫达非尼 脑药浓度 谷氨酸 

分 类 号：R965[医药卫生—药理学]