白细胞介素-18基因编码区105位点A/C多态性与冠心病易感性的关系  

Association of interleukin-18 gene 105A/C genetic polymorphism with susceptibility to coronary heart disease

作　　者：林粼[1] 李卫华[2] 赵岩[1] 张黎静[2] 

机构地区：[1]福建医科大学附属厦门第一医院中心实验室,福建厦门361003 [2]福建医科大学附属厦门第一医院心内科厦门市心血管疾病研究所

出　　处：《临床心血管病杂志》2010年第1期15-18,共4页Journal of Clinical Cardiology

摘　　要：目的:研究IL-18基因编码区105位点多态性与冠心病遗传易感性的关系。方法:采用多聚酶链反应限制性片段长度多态性分析法检测162例冠心病患者和134例对照者IL-18基因编码区105位点基因型,分析其与冠心病易感性的关系。结果:IL-18基因编码区105位点多态性中AA、AC、CC3种基因型在冠心病组和对照组中的频率分别为70.4%、29.0%、0.6%和88.1%、11.9%、0%。AC基因型患者患冠心病风险为AA基因型者的3.041倍(95%CI1.631～5.669),C等位基因携带者发生冠心病的风险是A等位基因携带者的2.806倍(95%CI1.556～5.061)(均P<0.01)。结论:IL-18基因编码区105位点多态性与福建地区部分汉族人群冠心病的发生存在相关性,携带AC、CC基因型人群发生冠心病风险较高。Objective：To investigate the association of interleukin-18 gene 105 genetic polymorphism in the coding region with susceptibility to coronary heart disease （CHD）.Methods：IL-18 gene 105 genotypes in 162 CHD patients and 134 controls were detected using PCR-restriction fragment length polymorphism（RFLP） assay,and the association of genetic polymorphism with susceptibility to CHD was analyzed. Results：The frequencies of A/A,A/C,C/C types of interleukin-18 gene 105 polymorphism in CHD patients and controls were 70.4%,29.0% and 0.6%vs 88.1%,11.9% and 0%. Compared with AA genotype,the relative risk for CHD in people with AC genotype was 3.041（95% confidence interval [CI] 1.631-5.669）. The relative risk for CHD in people with C allele was 2.806 higher than people with A allele（95%CI 1.556-5.061）（P〈0.01）. Conclusions：IL-18 gene 105 genetic polymorphism is associated with CHD in Han nationality of Fujian province,people with AC or CC genotypes take higher risk of suffering from CHD.

关 键 词：冠心病 白细胞介素-18 基因多态 

分 类 号：R541.4[医药卫生—心血管疾病]