ST段抬高型心肌梗死患者纤维蛋白原和D-二聚体的相关研究  

The relationship between plasma fibrinogen and D-dimer in patients with ST-elevation myocardial infarction

作　　者：李勇[1] 吕树铮[2] 孟康[2] 马临安[1] 李志忠[1] 郭路芬[1] 

机构地区：[1]北京市心肺血管病研究所首都医科大学附属北京安贞医院心肺血管抢救中心,北京100029 [2]北京市心肺血管病研究所首都医科大学附属北京安贞医院心内科

出　　处：《临床心血管病杂志》2010年第1期42-44,共3页Journal of Clinical Cardiology

基　　金：北京市科委重大科技支持项目(No:D0906006040191)

摘　　要：目的:探讨ST段抬高型心肌梗死(STEMI)患者与冠状动脉造影阴性的对照组纤维蛋白原和D-二聚体含量的差异。方法:选取2007-01-2008-08间STEMI并行直接冠状动脉介入治疗术(PCI)患者161例。同时选取冠状动脉造影阴性的对照组161例,比较2组间纤维蛋白原和D-二聚体含量。结果:STEMI患者血浆纤维蛋白原含量(2.47±0.89)g/L低于对照者(2.79±0.69)g/L,差异有统计学意义(t=-3.62,P<0.01)。STE-MI患者D-二聚体含量(μg/L)的平方根(10.96±5.66)高于对照者(9.13±5.04),差异有统计学意义(t=3.07,P<0.01)。STEMI患者血浆D-二聚体含量(μg/L)与纤维蛋白原含量(g/L)比值的平方根(7.52±4.56)高于对照者(5.63±3.29),差异有统计学意义(t=4.26,P<0.01)。结论:STEMI患者的纤维蛋白原低于冠状动脉造影阴性的对照组,D-二聚体高于对照组,提示在STEMI急性期存在急性血栓形成和继发性纤溶。Objective：To compare concentration of fibrinogen and D-dimer between patients with ST-elevation myocardial infarction（STEMI） and normal angiography of coronary artery.Methods：Patients （n=161） with STEMI were studied and patients （n=161） with normal coronary arteriograms were selected as a control,Beijing Anzhen Hospital,from Jan.2007 to Aug.2008. There were 131 males and 30 females in STEMI group and 131 males and 30 females in control group too.Plasma concentration of fibrinogen and D-dimer were compared between two groups. Result：Plasma concentration of fibrinogen were lower in ST EMI group（2.47±0.89）g/l than control group（2.79±0.69）g/l （t=-3.62,P〈0.01）.The square root of plasma concentration of D-dimer （μg/l） were higher in STEMI group （10.96±5.66）than control group（9.13±5.04）（t=3.07,P〈0.01）.The square root of the rate between D-dimer （μg/l）and fibrinogen（g/l） were higher in STEMI group （7.52±4.56）than control group（5.63±3.29）（t=4.26,P〈0.01）.Conclusion：The levels of fibrinogen in patients with STEMI were significantly lower than that of control,and D-dimer was opposite,which suggested the fresh thrombosis and fibrinolysis in STEMI patients.

关 键 词：冠状动脉疾病 ST段抬高型心肌梗死 纤维蛋白原 D-二聚体 

分 类 号：R541.4[医药卫生—心血管疾病]