变应性鼻炎伴哮喘患者特异性免疫治疗的疗效分析  

Efficacy evaluation of specific immunotherapy with standardized dermatophagoides pteronyssinus extract for allergic rhinitis accompanied with asthma

作　　者：陈建军[1] 孔维佳[1] 项济生[1] 舒宏[1] 施秋梅[1] 檀慧芳[1] 鲁忠元[1] 周月[1] 章许晶[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院耳鼻咽喉科,武汉430022

出　　处：《临床耳鼻咽喉头颈外科杂志》2010年第2期57-59,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：科技部十一五科技支撑计划"变应性鼻炎规范化诊断和防治体系的研究"(No:2007BAI18B15)

摘　　要：目的:探讨特异性免疫治疗对变应性鼻炎(AR)伴(不伴)哮喘患者的临床疗效。方法:155例患者,其中AR伴哮喘者40例,均符合免疫治疗入选标准,分为免疫治疗组及对照组。AR伴或不伴哮喘者分别进行观察。免疫治疗组以安脱达屋尘螨疫苗行特异性免疫治疗,对照组行单纯对症药物治疗。所有患者在治疗初始时记录鼻部及哮喘症状得分、用药得分、生活质量影响程度,1年观察结束后回访以上指标,并进行主观症状改善评价。结果:AR伴哮喘者免疫治疗组治疗1年后其鼻部及哮喘症状得分、用药得分、生活质量影响程度较治疗前明显改善,与对照组相比亦有明显差异。对照组中除用药得分外,其余指标治疗1年前后均未见明显差异。AR不伴哮喘者免疫治疗组及对照组治疗1年后其鼻部症状得分、用药得分、生活质量影响程度均较治疗前有显著改善,但免疫治疗组改善程度强于对照组。结论:AR伴哮喘者在临床上行单纯药物治疗疗效不佳,而行SIT可取得极佳的临床疗效。Objective：To evaluate the efficacy of specific immunotherapy（SIT） with standardized dermatophagoides pteronyssinus extract for allergic rhinitis（AR）accompanied with asthma.Method：One hundred and fifty-five patients（40 AR with asthma,AR asthma） in accordance with the inclusion criteria of SIT,were allocated to receive standardized Dermatophagoides pteronyssinus extract（SIT group,n=89） or medical treatment（control group,n=66）.AR with or without asthma was observed separately.Symptom and medicine scores,quality of life were recorded and analyzed before and after 1 year treatment.Side effects were registered.Subjective evaluation of symptoms was made by the patients.Result：Rhinitis and asthma symptom scores,medicine scores and quality of life were greatly improved in SIT group of AR asthma after 1 year,which were not significant changed in control group except for medicine scores.The subjective evaluation of symptoms was also significantly improved in SIT group.In patients of AR without asthma,the symptom scores,medicine scores and quality of life were both improved.The SIT group improved greater than that of control group.Conclusion：The clinical efficacy of patients with AR asthma was not good with simple medical treatment,while great clinical efficacy could be acquired with SIT.

关 键 词：鼻炎 变应性 哮喘 特异性免疫治疗 屋尘螨 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]