线性扫描极谱法测定盐酸二甲双胍  

Linear Scanning Polarographic Determination of Metformin Hydrochloride

作　　者：周云龙[1,2] 吴粦华[1] 胡志彪[1] 拓宏桂[1] 

机构地区：[1]龙岩学院化学与材料系,龙岩364000 [2]福州大学化学化工学院,福州350000

出　　处：《理化检验（化学分册）》2010年第3期235-237,共3页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：褔建省教育厅自然科学科研课题(JA03165)

摘　　要：用线性扫描极谱法研究盐酸二甲双胍的电化学行为。在pH6.85的0.1mol·L-1磷酸氢二钠-磷酸二氢钾缓冲溶液中,盐酸二甲双胍于-1.165V(vs.SCE)处产生一灵敏的吸附波,其一次微分线性扫描峰电流与盐酸二甲双胍质量浓度在0.41～41.0mg·mL-1范围内呈线性关系,检出限(3S/N)为0.28mg·mL-1。对41.0mg·mL-1盐酸二甲双胍溶液进行6次平行试验,相对标准偏差(n=6)为0.72%。此方法已用于测定其片剂中盐酸二甲双胍的含量。It was found that in a PBS of pH 6. 85 and by the linear scanning polarography, a sensitive adsorption wave of metformin was observed at the potential of -1. 165 V （vs. SCE）. Linear relationship between values of the 1st derivative of values of peak current and mass concentration of metformin was obtained in the range of 0. 41--41.0 mg ~ L-x with detection limit （3S/N） of 0. 28mg·L^-1. Precision was tested with standard solution of metformin hydrochloride of 41.0 mg· L^-1 for 6 determinations, value of RSD found was 0. 72%. The proposed method has been used in the determination of content of metformin hydrochloride in its tablets.

关 键 词：线性扫描极谱法 盐酸二甲双胍 吸附波 

分 类 号：O657.1[理学—分析化学]