骨形态发生蛋白4与哺乳动物卵泡发育的研究进展  

Progress on Bone Morphogenetic Protein 4 on Mammalian Follicular Development

作　　者：张驰[1] 周建设[1] 秦楠[1] 李明[1] 陈其新[1] 

机构地区：[1]河南农业大学牧医工程学院,郑州450002

出　　处：《中国畜牧兽医》2010年第3期141-144,共4页China Animal Husbandry & Veterinary Medicine

基　　金：河南省重点科技攻关项目(0524030011)

摘　　要：骨形态发生蛋白4(bone morphogenetic protein-4,BMP-4)属于转化生长因子超家族成员(TGF-β),参与机体的细胞生长、分化、凋亡、迁移及细胞外基质形成等众多病理、生理活动的调控。BMP-4基因与哺乳动物的繁殖性能密切相关,尤其在卵泡的生长分化过程中起着重要的调控作用,是原始卵泡和卵母细胞生存的必需因子。作者就骨形态发生蛋白4的基因结构、受体种类、信号调控机制及该基因与哺乳动物卵泡发育的关系作一综述。Bone morphogenetic proteins 4（BMP-4） is belonging to the transfer growth factor（TGF-β） superfamily.It involves in the cell of body growth,polarization,apoptosis,migration and the formation of extracellular matrix and many other pathological and physiological activity.Recent studies have shown that BMP-4 gene is closely related to the reproductive performance of mammals.It is a crucial factor in follicular growth and development in the mammalian ovary.In this review,the structure,function and regulation of BMP-4 were introduced.The relationships between BMP-4 gene and follicular development were also discussed in mammals.

关 键 词：骨形态发生蛋白4 信号调控机制 卵泡发育 

分 类 号：S814[农业科学—畜牧学]