大黄对重症急性胰腺炎患者血清TNF-α、IL-1β、IL-6影响的临床研究  

Effect of rude rhubarb on serum TNF-α,IL-lβ and IL-6 levels in patients with severe acute pancreatitis

作　　者：薛云平[1] 温志立[1] 付唆林[1] 

机构地区：[1]南昌大学第三附属医院消化二科,江西南昌330008

出　　处：《临床和实验医学杂志》2010年第8期566-567,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的对比研究经胃管和鼻空肠管不同途径给予大黄对重症急性胰腺炎(SAP)患者血清肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)和白细胞介素6(IL-6)的影响。方法SAP患者60例随机分为A组(n=20)、B组(n=20)和C组(n=20)。A组只行综合治疗,B组在综合治疗基础上给予胃管注入大黄,C组给予鼻空肠管注入大黄。观察患者入院时(0d)、7d时TNF-α、IL-1β、IL-6水平。结果入院0d时TNF-α、IL-1β、IL-6在三组中相互比较均无显著性差异(P>0.05)。治疗7d时三组TNF-α、IL-1β、IL-6检测值均比入院时下降,其中以C组下降最明显;三组之间TNF-α、IL-1β、IL-6检测值相互比较有显著性差异(P<0.05)。结论通过下调炎症递质的表达,鼻空肠管途径应用大黄能更有效的控制SAP的全身炎症反应。Objective To compare the effect of rude rhubarb on serum tumor necrosis factor （ TNF -α） , interleukin -1β （ IL -1β ） and interleukin- 6 （IL- 6） levels in patients with severe acute panereatitis （SAP） by nasogastric or nasojejunal feeding. Methods SAP patients were divided into group A （ n = 20）, B （ n = 20） and C （ n = 20） randomly. The patients in group A were given comprehensive treatment. On the basis of comprehensive treatment, the patients in group B were given rude rhubarb by nasogastric feeding, while those in group C were given by nasojejunal feeding. The serum levels of TNF - ct, IL -1β and IL - 6 in three groups were detected at different interval （ 0, 7 d）. Results On day 0, the serum levels of TNF - α, IL -1β and IL - 6 in three groups didnt show significant differences （ all P 〉 0.05 ）. On day 7, the serum levels of TNF - ct, IL -1β and IL - 6 in three groups decreased compared with those on day 0 （ obvious decrease was observed in group C ） ; In addition, the levels of TNF - c~, IL -1β and IL - 6 in three groups showed significant differences （ all P 〈 0.05 ）. Conclusion Administration of rude rhubarb by nasojejunal feeding can effectively control systemic inflammation in SAP patients by down - regulating the levels of TNF - α, IL -1β and IL -6.

关 键 词：重症急性胰腺炎 大黄 鼻空肠管 胃管TNF—α IL-1Β IL-6 

分 类 号：R259[医药卫生—中西医结合]