脂联素与2型糖尿病及其大血管并发症的相关性研究  

Study of correlation of serum adiponectin with type 2 diabetes and its macrovascular complications

作　　者：洪云[1] 单莉[1] 

机构地区：[1]淄博市中心医院内分泌科,山东255036

出　　处：《中国糖尿病杂志》2010年第3期207-208,共2页Chinese Journal of Diabetes

摘　　要：目的探讨脂联素(APN)与T2DM及其大血管并发症的相关性。方法测定正常人群(NC组)与单纯T2DM患者(T2DM组)及其大血管病变患者(T2DM+MA组)血清APN、胰岛素、血糖、血脂水平。结果 (1)血清APN水平T2DM组及T2DM+MA组较NC组降低,T2DM+MA组较T2DM组更低,差异有统计学意义;(2)APN水平与BMI、WHR、HOMA-IR、FIns、HbA_1c、TG负相关。结论 T2DM及其大血管病变患者血清APN水平的降低,可能与T2DM及其大血管并发症的发生发展密切相关。Objective To explore the correlation of adipnectin with T2DM and its macrovascular complications. Methods The levels of serum adiponectin, plasma glucose, serum lipids, and fasting insulin were measured in normal subjects, type 2 diabetic patients and type 2 diabetic patients with macrovascular complications. Results （1） The serum adiponectin level was significantly lower in type 2 diabetic patients than in normal subjects, and was the lowest in type 2 diabetic patients with macrovascular complications. （2） Serum adiponetin level was negatively correlated with BMI, HOMA-IR, HbAlc,TG and fasting insulin level. Conclusions The results suggest that lower serum adiponectin level may be related to macrovascular complications in type 2 diabetic patients.

关 键 词：糖尿病 大血管病变 脂联素 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]