血清抗内皮细胞抗体定量分析与子痫前期相关性研究  

Relationship between Antiendothelial cell antibodies and CRP with pre-eclampsia.

作　　者：吴振兰[1] 杜欣莹[1] 孙红[1] 

机构地区：[1]潍坊人民医院产二科,261041

出　　处：《中国优生与遗传杂志》2010年第3期69-70,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的观察抗内皮细胞抗体(antiendothelial cell antibodies,AECA)是否为中国人子痫前期(pre-eclampsia)的危险因素,并探讨AECA与C反应蛋白(CRP)二者间的关系。方法选择中晚期妊娠93例,其中病例组(子痫前期)37例,正常妊娠对照组56例。用ELISA法测血清AECA水平,散射比浊法测CRP定量。结果AECA水平是子痫前期发病的危险因素,病例组AECA水平明显高于对照组,独立样本T检验t=-4.581,P=0.000(OR值1.079,95%CI:1.012-1.151),差异有显著性意义;发生子痫前期的风险是正常人群的1.079倍。通过绘制ROC曲线确定AECA阳性标准为≥60.5 pmol/L,预测子痫前期的灵敏度是96.6%,特异度70.6%。CRP含量与AECA定量、妊娠结局及临床症状无相关关系,P>0.05。结论AECA水平与子痫前期发病密切相关,可较好预测子痫前期的发病;以AECA≥60.5 pmol/L作为子痫前期诊断指标,具有较高的灵敏度和特异度,有望成为一项新的临床诊断参考指标。CRP与AECA及子痫前期发病无关。Objective： The current study was undertaken to find out the interactions between antiendothelial cell antibodies in women with pre - eclampsia. Methods ： This study in 93 pregnancy women included two groups ： 37 patiens were pre - eclampsia and 56 control subjects with normal pregnancies. The AECA and CRP level were detected in all cases. Results： AECA level was significantly higher than that in control subjects, t = -4. 581, P =0. 000 （ 95% CI： 1. 012 - 1. 151 ） . The level of CRP was negatively in two groups, and it was not associated with the AECA too, P 〉0. 05. The cut -off value of positive AECA was determined as 360. 5 pmol/L with ROC curve. The sensitivity and specificity was 96. 6%, 70. 6%. Conclusion ： The elevated level of AECA is associated with the pre - eclampsia. AECA≥60. 5 pmol/L is a sensitive and specific indicator for diagnosing pre - eclampsia.

关 键 词：子痫前期 血清AECA水平 

分 类 号：R714.245[医药卫生—妇产科学]