左旋布比卡因臂丛神经阻滞的药代动力学  

Pharmacokinetics of levobupivacaine for brachial plexus block

作　　者：唐晓莉[1] 王承海[1] 孙考祥[2] 尚书军 邵伟[1] 

机构地区：[1]烟台市烟台山医院麻醉科,264001 [2]烟台大学药学院

出　　处：《临床麻醉学杂志》2010年第2期118-120,共3页Journal of Clinical Anesthesiology

摘　　要：目的研究左旋布比卡因用于臂丛神经阻滞的临床药代动力学特性。方法10例择期上肢手术患者,0.375%左旋布比卡因0.4ml/kg行肌间沟入路臂丛神经阻滞。于注药前及注药后10、20、30、45、60、90、120、180、240、360、480和720min采血2ml,分离血浆,高效液相色谱法测定左旋布比卡因血药浓度。所得数据经3P97药代动力学软件处理,选择最佳房室模型,绘出血药浓度-时间曲线,求得药代动力学参数。结果左旋布比卡因血药浓度-时间数据符合二房室开放模型,主要药代动力学参数:分布半衰期(t1/2α)(0.46±0.21)h、消除半衰期(t1/2β)(4.58±0.66)h、达峰时间(Tmax)(0.31±0.19)h、峰值浓度(Cmax)(0.95±0.31)mg/L、曲线下面积(AUC)(3.76±0.52)mg.h-1.L-1、清除率(CL)(0.42±0.07)L/h和表观分布容积(Vd)(1.34±0.44)L/kg。结论0.375%左旋布比卡因可安全用于臂丛神经阻滞,其临床药代动力学符合二房室开放模型。Objective To evaluate the pharmacokinetics of levobupivacaine for brachial plexus block（BPB）. Methods Interscalene BPB was performed with levobupivacaine 0. 375%（0.4 ml/kg） in 10 patients. Venous blood samples were collected for examing plasma concentrations of levobupivacaine before and at 10, 20, 30, 45, 60, 90, 120, 180, 240, 360, 480 and 840 min after injection by high-performance liquid chromatography. The pharmacokinetic parameters were determined with 3P97 software package. Results The plasma concentration-time curve was fitted to a two-compartment model with the main pharmacokinetic parameters of t1/2α （0. 46±0.21） h, t1/2β （4. 58 ±0.66） h,Tmax（0. 31±0. 19） h,Cmax（0. 95±0.31）mg/L,AUC （3.76±0. 52）mg·h^1·L^-1 ,CL（0. 42 ± 0. 07） L/h and Vd （ 1.34± 0.44） L/kg. Conclusion Levobupivacaine 0. 375% can be used for BPB safely. Its pharmacokinetics is fitted to a two-compartment model.

关 键 词：左旋布比卡因 臂丛神经阻滞 药代动力学 

分 类 号：R96[医药卫生—药理学]