雷米芬太尼药代动力学的年龄差异  

Age difference of remifentanil in pharmacokinetics

作　　者：张满和[1] 高金贵[2] 周秀敏[1] 

机构地区：[1]河北省唐山工人医院麻醉科,063000 [2]河北医科大学第二医院麻醉科

出　　处：《临床麻醉学杂志》2010年第2期127-128,共2页Journal of Clinical Anesthesiology

基　　金：河北省卫生厅医学科学研究重点资助课题(编号:05053)

摘　　要：目的研究雷米芬太尼药代动力学的年龄差异。方法ASAⅠ或Ⅱ级择期全麻老年组(65～82岁)及青壮年组患者(18～64岁)各60例,诱导时静注雷米芬太尼4μg/kg,于雷米芬太尼注射后1、2、3、5、7、10、15、20、25、30、45、60min分别采集动脉血1ml。采用液-液萃取毛细管气相色谱质谱法测定雷米芬太尼血药浓度。结果两组患者消除半衰期(t1/2β)[(18.1±9.2)minvs.(9.4±4.6)min]、表观分布容积(Vd)[(60.7±18.2)Lvs.(45.3±10.6)L]老年组明显高于青壮年组(P<0.05)。清除率(CL)[(2.1±0.3)L/minvs.(3.8±0.4)L/min]老年组明显低于青壮年组(P<0.05)。结论老年较青壮年患者雷米芬太尼的t1/2β延长、Vd增大和CL减低。Objective To study the age difference of remifentanil in pharrnacokinetics. Methods ASA class Ⅰ or Ⅱ patienls undergoing selective operation under general anestesia were assigned into group A （65 to 82 years old） and group B（18 to 64 years old） with 60 cases each. Remifentanil 4 μg/kg was infused during induction. Arterial blood samples 1 ml were taken at 1,2,3,5,7,10,15,20,25,30,45,60 min after injection and the concentrations of remifentanil were detected using liquid liquid extraction and capillary GCMS-SIM. Results The values of elimination halgtime（t1/2β）, volume distribution（Vd） and clearance（CI.） were signifieantly higher in group A than those in group B[t1/2β ,（18. 1±9.2） min vs. （9.4±4.6） min,Vd, （60.7±18.2） L vs. （45.3±10.6）L,CL,（2.1±0.3） L/min vs. （3.8±0.4） L/min] （P〈0.05）. Conclusion The t1/2β ,Vd and CL are significantly higher in the elderly than those in the younger.

关 键 词：雷米芬太尼 药代动力学 老年 

分 类 号：R96[医药卫生—药理学]