复方乌骨藤汤治疗晚期非小细胞肺癌的临床研究  

Compound wuguteng decoction in the treatmeat of advanced non-small cell lung cancer

作　　者：张炳谦 伍千国 

机构地区：[1]陕西省杨凌高新医院,杨凌712100

出　　处：《临床医学》2010年第1期112-114,共3页Clinical Medicine

摘　　要：目的观察和评价复方乌骨藤汤治疗晚期非小细胞肺癌的临床疗效和毒副作用。方法84例晚期非小细胞肺癌患者均经病理组织学检查确诊。复方乌骨藤汤每日3次,口服,4周为1个周期,共治疗2个周期。结果84例患者均可评价,完全缓解(CR)16例,部分缓解(PR)31例,稳定(SD)24例,恶化(PD)13例,患者的近期有效率56.0%,疾病进展时间(TTP)5.4个月,中位生存期11.2个月,1年生存率71.4%。主要毒副作用为个别患者血红蛋白减少,血小板减少和心电图异常,但均可以耐受。结论复方乌骨藤汤治疗晚期非小细胞肺癌有较好的临床疗效,毒副作用比较轻,患者均可以耐受,可改善患者的生存质量,延长生存时间。Objective To observe and evaluate the clinical effect and toxic and side reactions of the compound wuguteng decoction in patients with advanced non-small cell lung cancer.Methods The selection of 84 eligible patients were given oral compound wuguteng decoction 3 times per day for 2 therapeutic cycles,each cycles howing 4 weeks.Results All the cases were evaluable for efficacy,among the 84 cases,there were 16 cases of CR,31 cases of PR,24 cases of SD and 13 cases of PD.The recent effective rate was 56.0%.Median time to progerssion TTP was 5.4 months,median survival time was 11.2 months,and one yerar survival rate was 71.4%.The major toxic and side reaction included the decrease of hmoglobin,thrombocytopenia and electrocardiogram abnormality in a few cases.All the side effects could be tolerated by the patients.Conclusion The compound wuguteng decoction which is effective in the treatment of advanced non-small cell lung cancer with moderate side effects and safety in clinical practice,can improve the life（QOL） quality and increase the survival time of the patients.

关 键 词：非小细胞肺癌 复方乌骨藤汤 晚期 

分 类 号：R273[医药卫生—中西医结合]