门冬氨酸钾镁对心脏手术患者术后心律失常的预防和治疗作用  

Potassium and Magnesium Aspartate in Prevention and Treatment of Arrhythmia after Cardiac Operation

作　　者：赵东[1] 王振国[2] 李培军[3] 康凯[4] 卢成宝[5] 

机构地区：[1]复旦大学附属中山医院心外科,上海市200032 [2]天津武警医院 [3]天津市胸科医院 [4]哈尔滨医科大学附属第二医院 [5]上海市第一人民医院

出　　处：《中国全科医学》2010年第8期843-845,848,共4页Chinese General Practice

摘　　要：目的探讨门冬氨酸钾镁对心脏手术患者术后心律失常的预防和治疗作用。方法采用多中心、随机、平行、对照的方法,在术后(包括术后当天)连续3d分别给予试验组门冬氨酸钾镁、对照组氯化钾注射液适量静脉滴注,以维持血钾的正常水平。术后连续心电监测,记录患者心律、电解质及肾功能等指标。结果手术当天、术后第1天、术后第2天两组患者的补钾量比较,差异均有统计学意义(P<0.05);术前、术后试验组患者的血钾水平与对照组比较,差异均无统计学意义(P>0.05),在术前、术后即刻、术后当晚,试验组患者的血镁水平高于对照组,差异有统计学意义(P<0.05);术后试验组患者心房纤颤、房性期前收缩、室性期前收缩的发生率均低于对照组,心脏功能也较对照组改善明显。结论手术前后及时给予门冬氨酸钾镁补充钾、镁离子,与单纯补充氯化钾相比,能更有效地维持患者血钾水平、改善心脏功能并显著减少心律失常的发生。Objective To Investigate the prevention effects of potassium and magnesium aspartate on arrhythmia after cardiac surgery.Methods A multi-center,randomized,parallel and controlled method was used to give test group an appropriate intravenous infusion of potassium-magnesium aspartate and control group potassium chloride injection to maintain normal level of blood potassium.Postoperative continuous ECG monitoring was conducted and heart rate,electrolytes and renal function were recorded.Results There was significant difference in potassium supplement between 2 groups on surgery day,days 1,2 after operation （P〈0.05）,but there was not in blood potassium level （P〉0.05）.The level of magnesium ions was higher in test group than in control,the difference was significant （P〈0.05）.The incidence of fibrillation,atrial premature contraction,ventricular extrasystole and ventricular fibrillation was lower in test group than in control,and cardiac function improved more significantly.Conclusion Timely supplement of potassium-magnesium aspartate is more effective to maintain blood potassium,improve cardiac function and reduce significantly the incidence of arrhythmias than pure potassium chloride supplement.

关 键 词：门冬氨酸钾镁 心脏手术 心律失常 

分 类 号：R654.2[医药卫生—外科学]