吡格列酮对2型糖尿病患者氧化应激的影响  

Effect of Pioglitazone on Oxidative Stress in T2DM Patients

作　　者：殷松楼[1] 周冬梅[1] 奚珏[1] 庄玮[1] 殷寒秋[1] 

机构地区：[1]徐州医学院附属医院内分泌科,江苏省徐州市221002

出　　处：《中国全科医学》2010年第8期888-890,共3页Chinese General Practice

基　　金：徐州市科技计划项目(XM08C072)

摘　　要：目的探讨吡格列酮对2型糖尿病患者氧化应激的影响。方法收集于本院就诊的2型糖尿病患者130例,随机分成对照组和吡格列酮组,每组65例。对照组给予门冬胰岛素30和二甲双胍控制血糖;吡格列酮组使用门冬胰岛素30、二甲双胍和吡格列酮(15mg/d)降糖治疗,均治疗3个月。治疗前后检测并比较两组患者血清氧化应激指标:超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)。结果治疗后吡格列酮组患者血清SOD、GSH-Px活性〔(54±18)U/ml和(82±18)U/ml〕较治疗前〔(39±16)U/ml和(71±22)U/ml〕显著升高,MDA水平〔(2.6±1.7)nmol/ml〕较治疗前〔(3.8±2.3)nmol/ml〕显著降低,差异有统计学意义(P<0.05),且治疗后吡格列酮组上述3种指标与对照组〔(42±18)U/ml、(73±19)U/ml和(3.5±1.8)nmol/ml〕比较,差异有统计学意义(P<0.01)。结论吡格列酮能提高2型糖尿病患者血清SOD和GSH-Px活性,降低MDA水平,而且吡格列酮的这种作用不依赖于降糖作用。Objective To investigate the effects of pioglitazone on oxidative stress in T2DM.Methods One hundred thirty T2DM patients were randomized into groups control and Pioglitazone,65 in each.Control group were given insulin aspart 30 and metformin to control blood glucose;Pioglitazone group insulin aspart 30,metformin and Pioglitazone （15 mg/d） for hypoglycemic treatment.The treatments lasted 3 months.Serum oxidative stress indicators such as superoxide dismutase （SOD）,glutathione peroxidase （GSH-Px） and melondialdehyde （MDA） were determined before and after treatment.Results In Pioglitazone group,activities of SOD and GSH-Px were significantly higher after treatment （54±18 U/ml,82±18 U/ml,respectively） than before （39±16 U/ml,71±22 U/ml,respectively）,MDA level lower （2.6±1.7nmol/ml,3.8±2.3 nmol/ml,respectively）,the difference was significant （P〈0.05）.Pioglitazone group was different from control in the above 3 indicators （42±18 U/ml,73±19 U/ml,3.5±1.8 nmol/ml,respectively） after treatment,the difference was significant （P〈0.01）.Conclusion Pioglitazone can improve the activities of SOD,GSH-Px and reduce MDA level,not depending on hypoglycemic effect.

关 键 词：糖尿病 2型 噻唑烷二酮类 吡格列酮 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛 

分 类 号：R587.1[医药卫生—内分泌]