抗癌药物的电化学研究——Ⅰ.一种Fe(Ⅲ)Schiff碱配合物的基本电化学性质及其与DNA的相互作用  

Electrochemical Studies of Antitumor DrugsⅠ. Fundamental Electrochemical Characteristics of an Iron(Ⅲ) Schiff Base Complex and Its Interaction with DNA

作　　者：赵元弟[1] 庞代文[1] 王宗礼[1] 程介克[1] 乐芝凤[2] 冯长建[2] 沈昊宇[2] 张香才[2] 

机构地区：[1]武汉大学化学系,武汉430072 [2]华中师范大学化学系,武汉430070

出　　处：《化学学报》1998年第2期178-183,共6页Acta Chimica Sinica

基　　金：国家自然科学基金

摘　　要：研究了一种自合成的Schiff碱配合物的电化学行为及其与氧和DNA的相互作用.发现此种Schiff碱配合物能与氧发生相互作用而具有吸氧功能,并对氧的电还原有催化作用,同时还发现dsDNA能与此种Schiff碱配合物发生较强的相互作用,特别是Fe(Ⅱ)Schiff碱配合物更易与dsDNA结合.The fundamental electrochemical characteristics of a synthetic iron (Ⅲ) Schiff base complex has been studied. It has been found that the complex could interact with oxygen, thus being capable of absorbing oxygen. It exhibits catalytic activity toward the electroreduction of oxygen. The complex also interacts strongly with dsDNA, in particular, the iron(Ⅱ) form of the Schiff base complex is easier to bind dsDNA than the iron(Ⅲ) form. The biological activity and the pharmacological acting process of the Schiff base complex might be related to its absorbing of oxygen, catalytic activity and interaction with DNA.

关 键 词：铁 席夫碱 配合物 抗肿瘤药物 DNA 

分 类 号：O614.811[理学—无机化学] R979.1[理学—化学]