利多卡因对危重型支气管哮喘患者呼吸衰竭及气道峰压影响的临床研究  

Effects of Lidocaine on Respiratory Failure and the Airway Peak Pressure in Patients with Severe Asthma: A Clinical Research

作　　者：王承辉[1] 刘欢[1] 邬庆莲[1] 何碧云[1] 廖静洁[1] 

机构地区：[1]广西医科大学第四附属医院,柳州市545005

出　　处：《中国药房》2010年第10期913-914,共2页China Pharmacy

摘　　要：目的:观察利多卡因对危重型支气管哮喘患者呼吸衰竭及气道峰压的影响。方法:将机械通气治疗的支气管哮喘患者,随机分成治疗组与对照组,观察2组气道峰压、人机对抗及呼吸衰竭纠正时间等指标的变化。结果:对照组平均气道峰压为(41.18±10.66)cmH2O,治疗组为(29.23±9.07)cmH2O;对照组100%出现人机对抗,治疗组仅为40%;对照组呼吸衰竭纠正时间为(6.42±1.73)h,治疗组为(3.31±1.08)h。2组上述指标比较,差异均有统计学意义(P<0.01)。结论:利多卡因能解除支气管痉挛,降低气道峰压,减少人机对抗,值得在哮喘机械通气治疗的初期及早应用。OBJECTIVE： To observe the effect of lidocaine on respiratory failure and the airway peak pressure in patients with severe asthma. METHODS： The severe bronchial asthma patients treated with mechanical ventilation were randomly divided into treatment group and control group. The change in airway peak pressure, man-machine counteraction, and the correcting time of re- spiratory failure of the two groups were recorded. RESULTS： The average airway peak pressure was（41.18 ±10.66） cmH20 in the control group vs.（29.23 ±9.07） cmH2O in the treatment group; the incidence of man-machine counteraction was 100% for the control group vs. only 40% for the treatment group; the correcting time of respiratory failure was（6.42 ±1.73） h for the control group vs.（3.31 ±1.08） h for the treatment group. There were significant differences between the two groups in the above mentioned indexes（P〈0.01）. CONCLUSION： Lidocaine can relieve bronchospasm, lower airway peak pressure and reduce man-machine counteraction. It is worth of early application in the initial mechanical ventilation treatment stage of asthmatic patients.

关 键 词：危重型支气管哮喘 机械通气 利多卡因 气道阻力 

分 类 号：R969.3[医药卫生—药理学] R974.3[医药卫生—药学]