我院抗肿瘤药致不良反应162例报告分析  

Antineoplastic Medicine-induced Adverse Drug Reaction Reported in Our Hospital: Analysis of 162 Cases

作　　者：杨军炎[1] 顾小丽[1] 

机构地区：[1]江苏南通市肿瘤医院,南通市226361

出　　处：《中国药房》2010年第10期922-923,共2页China Pharmacy

摘　　要：目的:了解我院抗肿瘤药致不良反应发生的特点及规律。方法:收集我院2005～2008年抗肿瘤药致ADR报告162例,从患者性别、年龄、给药途径、合并用药情况、药品种类、累及器官或系统及临床表现等方面进行统计、分析。结果:162例ADR中,男女比例相近,60岁以上老年患者有68例,占41.98%;单一用药123例,占75.93%,合并用药39例,占24.07%;植物来源的抗肿瘤药的ADR居首位,占39.51%;ADR临床表现主要为皮肤及其附件损害,占36.42%。结论:临床应加强对抗肿瘤药致ADR监测工作,合理、规范使用抗肿瘤药,避免或减少严重ADR的发生。OBJECTIVE： To investigate the characteristics and regularity of antineoplastic medicine-induced adverse drug reaction （ADR） occurred in our hospital. METHODS： 162 antineoplastic medicine-induced ADR cases reported in our hospital from 2005 to 2008 were analyzed statistically in respect of patients＇ age and sex, categories of drugs, route of administration, drug combination, organs and systems involved in ADR and clinical manifestation, etc. RESULTS： Of the total 162 ADR cases, proportion of men was similar to women. 68 cases （41.98%） were old persons aged older than 60. 123 cases（75.93% ） were single use of drugs, 39 cases （24.07 % ） were combined use of drugs. 39.51% of ADR cases were induced by antineoplastic medicine made from plants and took up the first place in terms of incidence of ADR. 36.42% of ADR cases dominantly manifested as lesion of skin and its appendants. CONCLUSION： ADR monitoring of antineoplastic medicine should be strengthened to ensure rational and standardized use of antineoplastic medicine, avoid or reduce the occurrence of severe ADR.

关 键 词：药品不良反应 抗肿瘤药 报告 分析 

分 类 号：R969.3[医药卫生—药理学] R979.1[医药卫生—药学]