伴有代谢综合征的冠心病患者外周血小板平均体积变化的研究  

Changes of mean platelet volume in patients with coronary heart disease and metabolic syndrome

作　　者：李宝青[1] 叶映月[1] 葛海峰[1] 陈鹏[1] 吴朝明[1] 

机构地区：[1]温州医学院附属第二医院,浙江温州325027

出　　处：《中国卫生检验杂志》2010年第2期347-349,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨伴有代谢综合征(MS)的冠心病患者外周血小板平均体积的变化及其临床意义。方法:选择95例心绞痛型冠心病患者为冠心病组,根据冠心病组患者是否伴有MS分为2个亚组,伴MS组(25例)和不伴MS组(70例),同期选择健康体检者70例为正常对照组。测量身高、体重、血压,测定血糖、血脂和血小板参数如血小板计数(PLT)、血小板平均体积(MPV)等相关指标,分析MPV与伴有MS的冠心病之间的关系。结果:冠心病组患者外周血MPV(11.0±3.5)fl较正常对照组(8.9±0.50)fl明显增高(P<0.05)。伴MS组和不伴MS组的外周血MPV(11.6±5.3)fl和(10.7±5.3)fl均明显高于正常对照组(P<0.05),相关分析表明,MPV与BM I(r=0.371,P<0.01)、SBP(r=0.231,P<0.05)、DBP(r=0.211,P<0.05)、TC(r=0.292,P<0.01)、TG(r=0.268,P<0.05)、FPG(r=0.210,P<0.05)呈明显正相关,而与HDL-C呈明显负相关(r=-0.212,P<0.05);随着MS的组分增加,外周血MPV未表现出同步性增高,差异没有统计学意义(P>0.05)。结论:冠心病和MS之间关系密切,冠心病患者以及伴有MS的冠心病患者外周血MPV增高明显,提示患者体内存在血小板活化状态。Objective：To investigate the changes of platelet index in patients with coronary heart disease（CHD） and metabolic syndrome（MS）.Methods：95 patients with definite CHD and 70 normal control subjects were studied.The patients with CHD were divided into two subgroups,namely MS group（n=25） and non-MS group（n=70）,according to the criterion of Chinese Diabetes Society： Mean platelet volume（MPV）,Fasting plasma glucose（FPG）,total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein（LDL）,high-density lipoprotein（HDL） and body mass index（BMI） were measured.The relationships between platelet index and CHD,MS were analyzed.Results：MPV were significantly higher in CHD group（11.0±3.5）fl than in control group（8.9±0.50）fl mg/L,P0.05.MPV were significantly higher in CHD＋MS group（11.6±5.3）fl and non-MS group（10.7±5.3）fl than in the control group,（P0.05）;Analyses of results indicated that the MPV were correlated positively with BMI,SBP,DBP,TC,TG,FPG,（r=0.371,0.231,0.211,0.292,0.268 and 0.210,respecttively,P0.05）,and negatively with HDL（r=-0.210,P0.05）.Conclusion：MPV are significantly increased in CHD and CHD＋MS patients,which indicates that there is exist active platelets in these patients.

关 键 词：平均血小板体积 代谢综合征 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]