姜黄素缓释滴丸的制备及体外释放度考察  

Studies on Preparation and Dissolution Test in vitro of Sustained-release Dropping Pills of Curcumin

作　　者：方瑜[1] 向柏[1] 潘振华[1] 曹德英[1] 

机构地区：[1]河北医科大学药学院,河北石家庄050017

出　　处：《中药材》2010年第1期111-114,共4页Journal of Chinese Medicinal Materials

摘　　要：目的：对姜黄素缓释滴丸的处方和工艺进行研究,并考察其体外释放度。方法：以释放度为评价指标,采用正交设计实验优化处方。以滴丸成形性为评价指标,优化滴丸的制备工艺。结果：最佳处方为：硬脂酸70 mg,单硬脂酸甘油酯25 mg,聚乙二醇-12-羟基硬脂酸酯6 mg。释药行为符合Higuchi方程,具有明显的缓释特征。最佳工艺为：冷凝液粘度100 mm^2/s,料液温度80℃,冷却温度30-0℃,滴速（21±2）滴/min。结论：姜黄素缓释滴丸具有良好的体外缓释效果,可进一步进行体内释药行为考察。Objective： To study the prescription and technique of sustained-release dropping pills of curcumin and inspect their release property in vitro.Methods： The orthogonal test was used to screen the prescription and technique which were definited with the colligation evaluation of release and formation of dropping pills.Results： The optimization of prescription and technique were as follows： stearic acid 70 mg,glycery monostearate 25 mg,solutol 6 mg,viscosity of cooling liquid was 100 mm^2/s;the temperature of material liquid was 80 ℃;the cooling temperature was 30-0 ℃;the dropping speed was（21±2） dripping/min.The release behavior of sustained-release dropping pills of curcumin coincidented with Higuchi equation well and the character of sustained-release was transparent.Conclusions： The sustained-release dropping pills of curcumin have good property of sustained-release in vitro and their release behavior in vivo need to be inspected.

关 键 词：姜黄素 缓释滴丸 体外释放 

分 类 号：R944.2[医药卫生—药剂学]