Microstructures and properties of cancellous bone of avascular necrosis of femoral heads  

作　　者：Xuefeng Yao Peng Wang Ruchun Dai Hsien Yang Yeh 

机构地区：[1]Dai Department of Engineering Mechanics, AML, Tsinghua University, 100084 Beijing, China [2]Institute of Metabolism and Endocrinology,The Second Xiang-Ya Hospital, Central South University,410011 Changsha, China [3]Department of Mechanical and Aerospace Engineering, California State University, Long Beach, CA 90840-8305, USA

出　　处：《Acta Mechanica Sinica》2010年第1期13-19,共7页力学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(30470430 and 30400514)

摘　　要：The aim of this study is to investigate microscopic structure and characterize cancellous bone of avascular necrosis of the femoral head （ANFH）. The rabbit model of the ANFH is established. The histopathologic features are studied successfully. The differences between the steroidinjection group （S.G.） and the controlled group （C.G.） are examined, including the weight of rabbits, the hematological examination and the three-dimensional stnactures. It is found that the plasma levels of cholesterol （CHO）, high-density lipoprotein （HDL） and low-density lipoprotein （LDL） in S.G. are lower than those in C.G. when the triglyceride （TG） increased in the S.G.; but the bone mineral content （BMC） and the structural model index （SMI） of the organ and tissue decreased significantly in S.G. Three-dimensional structures of the femoral head are obtained using micro-computed tomography （CT） scanning and the mechanical model is established to analyze the influences of these structural changes on the mechanical properties of the cancellous bone.The aim of this study is to investigate microscopic structure and characterize cancellous bone of avascular necrosis of the femoral head （ANFH）. The rabbit model of the ANFH is established. The histopathologic features are studied successfully. The differences between the steroidinjection group （S.G.） and the controlled group （C.G.） are examined, including the weight of rabbits, the hematological examination and the three-dimensional stnactures. It is found that the plasma levels of cholesterol （CHO）, high-density lipoprotein （HDL） and low-density lipoprotein （LDL） in S.G. are lower than those in C.G. when the triglyceride （TG） increased in the S.G.; but the bone mineral content （BMC） and the structural model index （SMI） of the organ and tissue decreased significantly in S.G. Three-dimensional structures of the femoral head are obtained using micro-computed tomography （CT） scanning and the mechanical model is established to analyze the influences of these structural changes on the mechanical properties of the cancellous bone.

关 键 词：Avascular necrosis of the femoral head Cancellous bone MICROSTRUCTURE Mechanical properties 

分 类 号：S858.31[农业科学—临床兽医学] TG146.21[农业科学—兽医学]