含川芎嗪腹透液对腹膜透析效能的影响  

Influence of Ligustrazine-Contained Peritoneal Dialysate on Efficiency of Dialysis

作　　者：陆才生[1] 叶任高[1] 孙林[1] 李惠群[1] 郑智华[1] 戴健霞[1] 

机构地区：[1]中山医科大学第一附属医院肾脏病研究所,广州510080

出　　处：《中国中西医结合杂志》1998年第12期709-711,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：卫生部重点攻关项目基金资助课题!(No .970 40 2 2 8)

摘　　要：目的 :观察川芎嗪对腹膜透析效能的影响。方法 :采用自身前后对照设计 ,按腹膜平衡试验 (PET)结果将 2 4例稳定的持续非卧床腹膜透析 (CAPD)患者分为腹膜高转运 (4例 )、高于平均转运 (1 1例 )、低于平均转运 (8例 )、低转运 (1例 ) 4组 ,观察各组在腹透液中加入川芎嗪 (2 40mg/d)前后每透析周期平均净出超量 (UF)及每周尿素氮清除指数 (KT/V)的变化。结果 :加入川芎嗪后 2 4例患者的UF及每周KT/V值均有显著提高 (P <0 0 1 ) ,在不同腹膜转运的各组内 ,除高转运组 4例患者每周KT/V值升高未达到有显著统计学意义以外 ,每组的UF及其余组的每周KT/V值均有明显提高 (P <0 0 5 ,P <0 0 1 )。结论 :腹透液中加入川芎嗪能提高腹膜透析效能 ,增加出超量 ,值得进一步研究。Objective: To observe the influence of ligustrazine on efficiency of peritoneal dialysis. Methods: A prospective, self controlled study was adopted, 24 stable continuous ambulatory peritoneal dialysis (CAPD) patients were divided into 4 groups according to their peritoneal membrane solute transport types identified by peritoneal equilibration test (PET), the high transport group (H group, 4 cases), the high average transport group (Ha group, 11 cases), the low average transport group (La group, 8 cases) and the low transport group (L group, 1 case). After treated with standard dialysis for 2 weeks, patients were treated by peritoneal dialysis with ligustrazine (240 mg/d) contained dialysate for another 2 weeks, and changes on mean net ultrafiltration volume (UF) per exchange, and urea kinetics (KT/V) per week of patients were observed. Results: After ligustrazine treatment, the UF and KT/V raised significantly, P<0 01. In comparison of groups with different transportation, except change on UF of the H group was insignificant, increment of both parameters before and after treatment were significant (P<0 01 or 0.05). Conclusion: By adding ligustrazine in standard dialysate can enhance the efficiency of peritoneal dialysis, raise the UF, so is worth further study.

关 键 词：川芎嗪 腹膜透析 透析效能 

分 类 号：R459.5[医药卫生—治疗学]