小窝蛋白-1与肺纤维化关系的研究进展  

Research progress of relationship between caveolin-1 and pulmonary fibrosis

作　　者：丁辉[1] 周凤秋[1] 蔡后荣[1] 

机构地区：[1]南京医科大学附属鼓楼临床医学院呼吸内科,210008

出　　处：《国际呼吸杂志》2010年第6期366-369,共4页International Journal of Respiration

基　　金：南京市医学科技发展重点项目（ZKX08023）

摘　　要：小窝蛋白-1（Caveolin-1）是小窝标志性的蛋白，主要通过“脚手架”结构区域，参与负性调控多条信号通路，干预多种疾病进程。目前研究证实：特发性肺纤维化的肺组织中的Caveolin-1表达明显减低，而提高Caveolin-1水平抑制转化生长因子β1／Srnad、JNK、MEK／ERK、Wnt／β-Catenin／Lef-1等信号转导通路因子的激活，可减少细胞外基质的合成和上皮细胞的异常修复，阻断肺纤维化进程。深人研究Caveolin-1参与肺纤维化的分子机制，有望为特发性肺纤维化提供新的分子治疗靶点。As the character protein of caveolae, caveolin-1 negatively regulates many signaling molecules,and interferes the process of diseases by the caveolin scaffolding domain. It is reported that caveolin 1 expression obviously decreases in lung tissues of idiopathic pulmonary fibrosis. Over-expression of caveolin-1 could decrease synthesis of extraeellular matrix and abnormal reparation of epithelial cells, block the process of pulmonary fibrosis by inhibiting the molecular activation of transforming growth factor β1/Smad,JNK, MEK/ERK, Wnt/β-Catenin/Lef-1 signal pathways. It is hoped to provide novel molecular therapeutic targets for idiopathic pulmonary fibrosis that further study of molecular mechanism of caveolin-1 in pulmonary fibrosis.

关 键 词：小窝蛋白-1 特发性肺纤维化 转化生长因子Β1 信号通路 

分 类 号：R563.9[医药卫生—呼吸系统]