自贡地区肝炎病毒重叠感染研究  

A RESEARCHE ON SUPERINFECTION OF VIRAL HEPATITIS IN ZIGONG AREA.

作　　者：陈国忠[1] 缪以懋 郑高保 陈建鸿[1] 

机构地区：[1]四川省自贡市卫生防疫站,自贡643000

出　　处：《现代预防医学》1998年第4期430-432,共3页Modern Preventive Medicine

摘　　要：229例 HBV 感染者,用 ELISA 法检测抗 HCV、HDV—Ag 和抗 HDV。HBV 感染者的 HBV 与 HCV 二重感染率为27.95%;HBV、HDV 二重感染率为8.30%,HBV、HCV、HDV 三重感染率为5.68%。HBV 和 HCV 二重感染者,主要分布于 HCC、HLC,其次为 FHF、AVH。各临床型乙肝患者,HCV 感染率之间有显著性差异(X^2=35.75,P<0.005)。64例 HBV 和 HCV 二重感染者与125例单纯 HBV 感染者 e 抗原比较也有显著性差异(X^2=15.80,P<0.005),表明 HCV 感染似有抑制 HBV 复制,使病程迁延加重的可能。HBV、HCV、HDV 三重感染者与单纯 HBV 感染者 e抗原检出率无差异(P>0.05)。这些结果提示,乙、丙、丁型肝炎重叠感染者比单一感染者预后差,病情重,病程长,重叠感染可能是乙肝慢性化活动性,反复急性发着的主要原因。By ELISA method,the anti-HCV,HDVAg and anti-HDV in 229 cases with HBV infection had been detect- ed.The superinfection rates of HBV and HCV,HBV and HDV,HBV,HCV and HDV among HBV infection cases were 27.95%,8.30% and 5.68% respectively.The superinfection of HBV and HCV most distributed in HCC and HLC,FNF and AVH were the second.There were significant difference between various clinic types of HBV infection and HCV infection rate(x^2=35.75,P<0.005).It indicated that HCV infection seems to con- trol HBV replication,and to be able to worsen the course of disease.The antigen e of triple infection cases with HBV,HCV and HDV were not different from that of HBV single infection cases(P>0.05).It sugested,those cases with superinfection of B.C and D hepatitis viruses had worse prognosis,more serious illness and more de- ferred course of disease than HBV single infection.Probably this is main reason that super infection of hepatitis B is easier to chang to chronic and active hepatitis.

关 键 词：肝炎病毒 重叠感染 复制 

分 类 号：R512.602[医药卫生—内科学]