大气细颗粒物暴露对人体免疫指标的影响  

Effects of airborne fine particulate matters on human immunological indicators

作　　者：高知义[1] 李朋昆[1] 赵金镯[1] 蒋蓉芳[1] 杨斌杰[2] 章敏华[2] 宋伟民[1] 

机构地区：[1]复旦大学公共卫生学院环境卫生教研室公共卫生安全教育部重点实验室,上海200032 [2]上海市疾病预防控制中心

出　　处：《卫生研究》2010年第1期50-52,共3页Journal of Hygiene Research

基　　金：国家863专题项目(No.2007AA06Z400)

摘　　要：目的研究大气细颗粒物污染对人体免疫学指标的影响。方法使用个体采样器监测上海市区外勤交通警察和小区居民大气细颗粒物暴露水平,检测免疫学指标:白细胞计数(WBC)、中性粒细胞计数(NE)、中性粒细胞比率(NE%)、淋巴细胞计数(Ly)、淋巴细胞比率(Ly%)、CD4+、CD8+、CD4+/CD8+及免疫球蛋白IgA、IgM、IgG和IgE,比较交警和居民细颗粒物暴露及免疫学指标的差异。结果交警组大气细颗粒物暴露水平[(115.4±46.2)μg/m3]显著高于普通居民[(74.9±40.1)μg/m3](P<0.01),两组Ly%、CD4+、CD8+、IgM、IgG、IgE、Clara细胞蛋白(CC16)及C反应蛋白(CRP)水平差异有显著性(P<0.05或P<0.01)。结论长期暴露于高浓度大气细颗粒物可导致血液中某些免疫指标发生改变,影响免疫系统健康。Objective To explore effects of airborne fine particulate matters on human immunological indicators.Methods All subjects were measured the level of PM2.5 individual exposure with personal sampling devices.Serum immunological indicators,such as WBC,NE,NE%,Ly,Ly%,CD4＋,CD8＋,CD4＋/CD8＋,IgA,IgM,IgG and IgE were detected through enzyme-linked immunosorbent assay.Then,comparing the difference of PM2.5 exposure and immunological indicators between two groups.Results For the level of PM2.5 daily exposure,traffic policemen（（115.4±46.2）μg/m3 ） was significantly higher than residents（（74.9±40.1）μg/m^3 ）.And there was also significant difference in some immunological indicators,such as Ly%,CD4＋,CD8＋,IgM,IgG,IgE,CC 16 and CRP,between two groups.Conclusion Long-term high level of airborne fine particulate matters exposure may change some blood immunological indicators,affect the health of the immune system.

关 键 词：大气细颗粒物 免疫球蛋白 CC16 C-反应蛋白 环境污染 

分 类 号：R122[医药卫生—环境卫生学] X503.1[医药卫生—公共卫生与预防医学]