萘酚喹治疗间日疟的疗效观察  

OBSERVATION ON EFFICACY OF NAPHTHOQUINE AGAINST VIVAX MALARIA

作　　者：单成启[1] 刘光裕[1] 焦岫卿[1] 

机构地区：[1]军事医学科学院微生物流行病研究所

出　　处：《中国寄生虫病防治杂志》1998年第4期275-276,共2页Chinese Journal of Parasitic Disease Control

摘　　要：在海南省疟疾流行区，用萘酚喹６００ｍｇ顿服和氯喹１．５ｇ标准疗法各治疗间日疟病人３５例，服药后两组病例均获即时治愈。萘酚喹组平均退热和原虫转阴时间分别为（２２．７±７．４）ｈ和（４６．４±９．７）ｈ；氯喹组平均退热和原虫转阴时间分别为（１９．１±８．３）ｈ和（４１．６±８．２）ｈ。随访６ｗｋ，萘酚喹组的治愈率为１００％，氯喹组为７４．３％。结果表明，萘酚喹治疗间日疟的远期效果明显优于氯喹（Ｐ＜０．０１）。Thirty five patients with vivax malaria were treated by naphthoquine 600 mg(single oral administration) and another 35 cases were treated by chloroquine 1.5 g in a malarial epidemic area of Hainan Province. All the cases achieved clinical cure. The mean defervescence time and mean parasite clearance time for naphthoquine treatment group were (22.7±7.4) h and (46.4±9.7) h respectively. The same parameters for chloroquine treatment group were (19.1±8.3) h and (41.6±8.2) h. The cure rate for naphthoquine and chloroquine in 6 weeks were 100% and 74.3% respectively. Therefore, the long term effect of naphthoquine was higher than that of chloroquine.

关 键 词：萘酚喹 氯喹 间日疟 疟疾 治疗 

分 类 号：R531.305[医药卫生—内科学]