活络通痹方治疗糖尿病周围神经病变30例临床观察  

Clinical research of Huoluo Tongbi decoction on the treatment of diabetic peripheral neuropathy

作　　者：唐爱华[1] 李双蕾[1] 周卫惠[1] 钟金清[1] 邓小敏[1] 赵伟[1] 

机构地区：[1]广西中医学院第一附属医院内分泌科,广西南宁530023

出　　处：《河北中医》2010年第1期18-20,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察活络通痹方治疗糖尿病周围神经病变疗效。方法60例患者随机分为治疗组30例和对照组30例。在常规治疗上,治疗组予活络通痹方,对照组予维生素B1、B12肌肉注射,2组均8周为1个疗程。1个疗程后观察2组患者治疗前后临床症状及空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbAlc)、血清胰岛素样生长因子-1(IGF-1)、血脂、血液流变学及神经传导速度等变化。结果2组总有效率比较差异有统计学意义(P<0.05),治疗组临床疗效优于对照组;治疗组治疗后FPG、2hPG、HbAlc、IGF-1、血脂、血液流变学及神经传导速度(NCV)各项指标与本组治疗前及对照组治疗后比较差异均有统计学意义(P<0.05),治疗组优于对照组。结论活络通痹方能有效改善DPN患者临床症状,改善其血脂和血液黏稠度,并能提高患者的神经传导速度,降低FPG、2hPG及HbAlc水平,提高IGF-1水平,对糖尿病周围神经病变具有较好的防治作用。Objective To observe the clinical efficacy of Huoluo Tongbi decoction on the treatment of DPN,and to explore its mechanism.Methods Sixty patients were allocated to the treatment group（n=30）and control group（n=30）randomly.The patients of two groups were given conventional treatment.The patients in treatment group were taken Huoluo Tongbi decoction.The patients in control group were treated by intramuscular of vitamin B1 and vitamin B12.The treatment period lasted 8 weeks.The clinical symptoms and the changes in FBG,PBG,HbA1C,IGF-1,lipid,hemorrheology,nerve conduction velocity,etc.were observed.Results The total effective rates of the treatment group was higher than that of the control（P0.05）.Treatment group＇s TC,TG,LDL-C and hemorheology were significantly decreased after the treatment,those changes were better than those in the control group（P0.05 or P0.01）.Serum IGF-1 level and nerve conduction velocity in two groups were significantly increased after treatment（P0.01）.And the treatment group＇s increased more significantly,that was better than those of the control group（P0.05 or P0.01）.Conclusion Huoluo Tongbi decoction can effectively improve the clinical symptoms in patients with DPN,which improve their blood lipids and blood viscosity.And it can improve the nerve conduction velocity and serum IGF-1 level,which has a better effect in prevention and treatment of DNP.

关 键 词：糖尿病并发症 周围神经系统疾病 中医药疗法 汤剂 

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