拉莫三嗪血药浓度与疗效的关系  

The Study for the Relation Between the Serum Concentration of Lamotrigine and its Effect

作　　者：王颖慧[1] 王丽[1] 王云秀[1] 吴晔[1] 

机构地区：[1]北京大学第一医院,北京100034

出　　处：《儿科药学杂志》2010年第2期30-32,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨拉莫三嗪(LTG)与其它抗癫痫药物的相互作用及对癫痫发作频率的影响,分析拉莫三嗪血药浓度与疗效的关系。方法:对收集的病例进行分组,对所得的数据进行卡方检验、方差分析与相关性分析。结果:丙戊酸钠使LTG的血药浓度升高,卡马西平使LTG的血药浓度降低,单药LTG服药剂量与血药浓度明显相关(r=0.889,P<0.05),各组疗效具有明显差异(χ2=22.508,P<0.05)。结论:LTG的血药浓度和服药剂量与联合的抗癫痫药物以及病人的个体差异相关,因此需要在治疗的过程中进行治疗药物监测以便更好的控制癫痫。Objective：To explore the the reciprocity of lamotrigine （LTG）, valproate （VPA）, carbamazepine （CBZ） and other antiepileptic drugs and analyze the relativity between blood concentration of LTG and clinical response. Methods： All cases were divided into 5 groups, then ANOVA, Х^2 and relativity analysis were employed. Results： VPA combination enhanced LTG blood concentration, CBZ combination reduced LTG blood concentration. Obvious relativity between blood concentration of LTG and LTG maintaining dose was observed in the cases of LTG monotherapy （ r = 0. 889, P 〈 0.05 ）. Clinical response of 5 groups were obviously different （Х^2 = 22. 508, P 〈 0.05）. Conclusions： Serum concentration and maintaining dose of LTG are effected by many factors, such as, other anti-epilepsy drugs and individual difference. Therefore TDM is an essential tool to control seizure.

关 键 词：拉莫三嗪 丙戊酸钠 卡马西平 治疗药物监测 

分 类 号：R969.3[医药卫生—药理学] R971.6[医药卫生—药学]