人β防御素-2抗唾液支原体活性研究  

作　　者：王玉爱[1] 刘志杰[1] 

机构地区：[1]湖南怀化医学高等专科学校医学检验系,418000

出　　处：《当代医学》2010年第10期10-11,共2页Contemporary Medicine

摘　　要：目的探讨人β防御素-2(hBD-2)在抗唾液支原体中的作用。方法用唾液支原体感染牙龈上皮细胞HGEC,RT-PCR检测hBD-2的表达情况;将培养的唾液支原体中加入不同浓度的hBD-2,检测其生长情况。结果唾液支原体能诱导HGEC表达hBD-2,且hBD-2能明显抑制唾液支原体的生长。结论hBD-2可能在抗唾液支原体感染过程中起关键作用。Objective This study was designated to investigate the antibacterial activity of human β -defensin-2（hBD-2） to Mycoplasma salivarium. Methods Gingival epithelium cells （HGEC） were infected with M. salivarium, expression of hBD-2 was detected by RT-PCR; Cultured M. salivarium cells were incubated with hBD-2 for various times, the antibacterial activity was assessed. Results M.salivarium could induce HGEC expression of hBD-2, and hBD-2 could inhibit M. salivarium grouth. Conclusion hBD-2 might play important roles after M.salivarium infection

关 键 词：人Β防御素-2 抗菌活性 唾液支原体 

分 类 号：R450[医药卫生—治疗学]