β1肾上腺受体Arg389Gly多态性与β1受体阻滞剂降压疗效的相关性研究  

β1-adrenergic receptor polymorphisms influence the response to bisoprolol monotherapy in patients with essential hypertension

作　　者：彭应心[1] 薛浩[2] 姚文静[1] 曹东平[1] 韩玉平[1] 李秀芳[1] 

机构地区：[1]河北省人民医院心脏中心,河北050051 [2]解放军总医院心内科,北京100853

出　　处：《中国分子心脏病学杂志》2010年第1期51-53,60,共4页Molecular Cardiology of China

摘　　要：目的探讨β1肾上腺素受体(β1-Adrenergic Receptor,ADRB1)Arg389Gly基因多态性与ADRB1阻滞剂降压疗效的相关性。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析412例原发性高血压患者ADRB1Arg389Gly基因多态性,将患者分成Arg389Arg组,Arg389Gly组和Gly389Gly组,观察比索洛尔治疗8周后血压变化的组间差异。结果比索洛尔治疗8周后,Arg389Arg组,Arg389Gly组和Gly389Gly组收缩压(SBP)分别下降了12.1%±4.5%,3.4%±4.1%和1.3%±1.0%,舒张压(DBP)分别下降了6.9%±4.4%,2.5%±4.1%和0.8%±4.0%,修改为收缩压(SBP)分别下降了(12.1±4.5)mmHg,(3.4±4.1)mmHg和(1.3±1.0)mmHg,舒张压(DBP)分别下降了(6.9±4.4)mmHg,(2.5±4.1)mmHg和(0.8±4.0)mmHg。组间比较差异均有统计学意义(均P<0.01)。结论ADRB1的Gly389Arg基因多态性与比索洛尔降压疗效相关。Objective To investigate that β1-adrenergic receptor polymorphisms affect the blood pressure response to β-adrenoceptor blockade （bisoprolol） monotherapy in the Chinese population with hypertension.Methods 412 patients with essential hypertension were recruited from outpatient.β1-adrenergic receptor polymorphisms were genotyped by using polymerase chain reaction-restriction fragment length polymorphism.The patients were divided by three groups according to the genotypes,including 201 for Arg389Arg,168 for Arg389Gly,42 for Gly389Gly.All the patients were given bisoprolol every day for 8 weeks.Heart rate and blood pressure were measured weekly during the duration of bisoprolol therapy.Results Systolic blood pressure after bisoprolol administration was significantly different among three groups （12.1%±4.5%,3.4%±4.1% and 1.3%±1.0% for Arg389Arg,Gly389Arg and Gly389Gly,respectively,P〈0.01）.We also found a similar difference in changes of diastolic blood pressure （6.9%±4.4%,2.5%±4.1% and 0.8%±4.0% respectively,P 0.01） for Arg389Arg,Gly389Arg and Gly389Gly patients.Conclusion β1-adrenergic receptor polymorphism was associated with different blood pressure responses to bisoprolol therapy in patients with essential hypertension.[HTH]

关 键 词：原发性高血压 比索洛尔 受体阻滞剂 Β-肾上腺素能 降压疗效 基因多态性 限制性片段长度多态性 高血压患者 不同基因型 比较差异 

分 类 号：R544.1[医药卫生—心血管疾病]