社区人群中血浆人组织激肽释放酶含量与血脂的关系  

The association of plasma TK levels with lipid in community groups

作　　者：张琴[1] 冉晓[2] 汪道文[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院高血压研究所,武汉市430040 [2]华中科技大学同济医学院附属同济医院急诊科,武汉市430030

出　　处：《中国分子心脏病学杂志》2010年第1期57-60,共4页Molecular Cardiology of China

基　　金：国家973重点基础研究发展规划资助项目(No.2006CB503801);国家"863"计(No.2006AA02A406)

摘　　要：目的检测社区正常人群中血浆激肽释放酶(TK)的含量,并研究其与血脂的关系。方法采用生物素-亲和素双抗体夹心ELISA法检测检测1881名社区人群的血浆TK含量,绘制TK含量的分布图并用相关分析和偏相关分析来评估血浆TK含量与血脂的相关关系。结果社区人群血浆中TK含量服从正偏态分布(Skewness=1.297,SE=0.058,Kurtosis=3.896,SE=0.115)。血浆TK的含量与高密度脂蛋白(HDL)成正相关关系(r=0.069,P=0.003),与低密度脂蛋白(LDL)成负相关关系(r=-0.051,P=0.030)。结论血浆脂蛋白的水平可能与血浆TK含量有关。Objective to detect plasma tissue kallikrein （TK） levels in normal people and investigated the association of plasma TK with lipid.Methods double antibody sandwich with biotin-avidin ELISA were used to detected plasma TK levels in 1881 normal person.We described the distribution of plasma TK and perfumed analysis with bivariate correlation and partial correlation.Results Plasma TK in community groups subjected to positively skewed distribution （Skewness=1.297,SE=0.058,Kurtosis=3.896,SE=0.115）.Plasma TK levels had direct correlation with high density lipoprotein（r=0.069,P=0.003） and inverse correlation with low density lipoprotein（r=-0.053,P=0.025）.Considering the influence factor of lipid,plasma TK levels still had direct correlation with high density lipoprotein（r=0.055,P=0.001） and inverse correlation with total cholesterol （r=-0.069,P=0.018） and low density lipoprotein（r=-0.053,P=0.025）.Conclusion there may exist relationship between plasma TK and plasma lipoprotein.

关 键 词：人组织及肽释放酶 血脂水平 社区人群 组织激肽释放酶 血浆脂蛋白 负相关关系 正相关关系 偏相关分析 低密度脂蛋白 正常人群 

分 类 号：R543[医药卫生—心血管疾病] R541.4[医药卫生—内科学]